胰腺癌组织β_2肾上腺素受体蛋白表达及临床意义  

EXPRESSION OF β_2-ADRENOCEPTOR IN PANCREATIC CANCER AND ITS CLINICAL SIGNIFICANCE

作　　者：薛晶[1] 李玉军[2] 李宏[2] 孙显路[2] 

机构地区：[1]青岛大学医学院病理学教研室,山东青岛266003 [2]青岛大学医学院附属医院病理科

出　　处：《齐鲁医学杂志》2011年第3期197-199,共3页Medical Journal of Qilu

基　　金：青岛市科技局资助项目(09-1-1-14-nsh)

摘　　要：目的探讨β2肾上腺素受体(β2-AR)在胰腺癌组织表达及其与胰腺癌临床病理特征之间的关系。方法采用免疫组织化学技术,检测40例胰腺癌及10例远癌正常胰腺组织中β2-AR的表达情况,分析β2-AR表达与胰腺癌临床病理特征之间的关系。结果胰腺癌组织β2-AR的阳性表达率为77.5%(31/40),正常胰腺组织为40.0%(4/10),二者之间差异有显著性(Z=-22.475,P<0.05)。胰腺癌组织中β2-AR蛋白阳性表达与TNM分期及有无淋巴结转移有关(Z=-3.372-、3.073,P<0.05),而与病人的性别、年龄、肿瘤大小、分化程度无关(Z=-1.395～-0.060,P>0.05)。结论β2-AR蛋白在胰腺癌浸润转移中发挥着重要作用,β2-AR阻断剂有可能用于胰腺癌的预防和治疗。Objective To investigate the expression of β2-adrenoceptor（β2-AR） in pancreatic cancer and its relationship with clinicopathologic parameters. Methods The expression of β2-AR was detected by immunohistochemistry in 40 tissue specimens of cancer of pancreas and 10 normal pancreatic tissue that away from the cancer.The association of β2-AR expression with clinicopathologic parameters was analyzed. Results The positive rate of β2-AR expression was 77.5%（31/40） in cancer specimens,and 40.0%（4/10） in normal pancreatic tissue,the difference between the two groups being significant（Z=-2.475,P0.05）.In cancer of pancreas,the positive expression of β2-AR was correlated with TNM staging and whether or not with metastasis of lymph node（Z=-3.372,-3.073;P0.05）;but not with the gender,age,size of tumor and degree of differentiation（Z=-1.395——0.060,P0.05）. Conclusion β2-AR plays an important role in infiltration and metastasis of pancreatic cancer,β2-AR-blocking agent might be used in the prevention and therapy for this malignancy.

关 键 词：胰腺肿瘤 Β2肾上腺素受体 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]