缺血性脑血管病病人SAA水平检测与意义  

DETERMINATION AND SIGNIFICANCE OF SAA IN PATIENTS WITH ISCHEMIC CEREBROVASCULAR DISEASE

作　　者：战晶晶[1] 金丽英[1] 王海萍[2] 张晨[2] 宋岩[1] 

机构地区：[1]青岛大学医学院,山东青岛266021 [2]青岛大学医学院附属医院神经内科

出　　处：《青岛大学医学院学报》2011年第2期110-112,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省教育厅科技攻关项目(2007GG30002031)

摘　　要：目的探讨血清淀粉样蛋白A（SAA）在缺血性脑血管病中的作用。方法采用ELISA方法,检测动脉粥样硬化性脑梗死急性期病人50例、动脉粥样硬化性脑梗死非急性期病人40例、短暂性脑缺血发作（TIA）病人36例血清SAA与基质金属蛋白酶-9（MMP-9）水平,采用放射免疫比浊法测定C-反应蛋白（CRP）水平,并以50例健康体检者作为对照。结果脑梗死急性期组血清SAA水平高于脑梗死非急性期组、TIA组及对照组（F=49.51,q=15.7~20.0,P〈0.01）。脑梗死急性期和TIA病人血清SAA水平与CRP及MMP-9水平呈明显正相关性（r=0.511、0.560,P〈0.01）。结论 SAA作为动脉粥样硬化的炎性标志物,参与了动脉粥样硬化性脑梗死的形成,SAA可作为不稳定斑块破裂的早期预警指标。Objective To explore the role of serum amyloid A（SAA） protein in ischemic cerebrovascular disease.Methods Using enzyme linked immunosorbent assay（ELISA）,serum SAA and matrix metalloproteinase-9（MMP-9） were detected in 50 patients with acute atherosclerotic infraction,40 with non-acute atherosclerotic infraction,and 36 with transient ischemic attack（TIA）;and C-reactive protein was detected by immunoturbidimetry.Fifty health subjects served as the control. ResultsThe serum level of SAA in acute infraction group was higher than that in non-acute infraction,TIA and the control（F=49.51;q=15.7-20.0;P0.01）.The serum levels of C-reaction and MMP-9 were positively correlated with that of SAA in acute infarction and TIA patients（r=0.511,0.560;P0.01）. Conclusion SAA-as an inflammatory marker of atherosclerosis-is involved in the formation of atherosclerotic brain infarction,this marker can be used as an early warning of unstable plaque disruption.

关 键 词：动脉粥样硬化 脑血管障碍 血清淀粉样蛋白A 

分 类 号：R743.3[医药卫生—神经病学与精神病学]