粘附因子CD_(44)v3在正常绒毛和葡萄胎中的表达及相关性研究  

Expression of CD_(44)v3 and Their Correlation in Normal Placetal Villi and Hydatidiform Mole

作　　者：白兴武[1] 

机构地区：[1]承德护理职业学院,河北承德067000

出　　处：《河北医学》2011年第4期451-453,共3页Hebei Medicine

基　　金：河北省科技厅资助项目编号:08276101-61

摘　　要：目的:探讨CD44v3在正常绒毛和葡萄胎中的表达及相关性。方法:采用免疫组化SABC法检测CD44v3在50例正常绒毛,50例良性葡萄胎,40例恶性葡萄胎的表达情况。结果:CD44v3在正常绒毛,良性葡萄胎,恶性葡萄胎中阳性表达率分别是:8.0%,30.6%,90.0%,组间比较差异有统计学意义(P<0.05)。结论:CD44v3的过表达促进葡萄胎的浸润、转移,可作为葡萄胎的浸润、转移及评价预后生物学指标。Objective： villi and hydatidiform mole. placetal villi ,50 specimens To investigate the expression of CD44v3 and their correlation in normal placetal Method ： The expression of CD44 v3 protein was detected in 50 specimens nomal benign hydatidiform mole and 40 specimens of malignant hydatidiform mole by immunohistochemistry （ SABC method ）. Result： In normal placetal villi, benign hydatidiform mole, malignant hydatidiform mole ,the expression rate of CD44 v3 were 8.0% , 30.6% and 90.0% respectively . Conclusion：The expressions of CD44v3 are correlated to invasion and metastasis of hydatidiform mole, thus can be as markers to predict metastasis and invasion of hydatidiform mole and the orognosis of these natients as well.

关 键 词：免疫组化 CD44V3 正常绒毛 葡萄胎 

分 类 号：R737.33[医药卫生—肿瘤]