青少年双生子腰臀比遗传度研究  

HERITABILITY ANALYSIS OF WAIST-HIP RATIO FOR ADOLESCENT TWINS

作　　者：张栋[1,2] 逄增昌[3] 吴伟风[1] 宁峰[4] 段海平[3] 兰金凤[1] 王福建[1] 张东峰[1] 

机构地区：[1]青岛大学医学院,山东青岛266021 [2]胶南市疾病预防控制中心 [3]青岛市疾病预防控制中心 [4]芬兰赫尔辛基大学

出　　处：《青岛大学医学院学报》2011年第1期11-13,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：国家自然科学基金资助项目(30872170)

摘　　要：目的采用经典的双生子设计探讨遗传因素和环境因素对青少年体型指征腰围、腰臀围比值（WHR）的影响程度。方法选择青岛地区自愿参加本研究的327对11~19岁双生子为研究对象,相同性别和血型的双生子采用16个多态标记进行卵性鉴定,在此基础上,应用SPSS 15.0软件及Mx软件进行数据处理,通过构建结构方程模型分析计算体型指征相关指标的遗传度。结果调整年龄、性别后,得出青岛市青少年双生子腰围的遗传度为0.08,WHR的遗传度为0.53。结论青少年双生子体型指征WHR在受遗传因素影响的同时也在一定程度上受到环境因素的影响,而腰围则主要受环境影响。Objective To investigate the impact of inheritance on waist circumference and waist-hip ratio（WHR） in adolescent by the classic twin design.Methods This study recruited volunteers in Qingdao from 327 pairs of twins,aged 11-19 years.Zygosity in all same-sex and same-blood-group twin pairs was determined by 16 polymorphic markers.Based on zygosityidentification,SPSS and Mx software package were used as statistical methods to build structural equation models.Heritability was assessed by structural equation models.Results After adjusting sex and age,the heritability of waist circumference and WHR were 0.08 and 0.53,respectively.Conclusion In addition to gene factor,environmental factors also influence the WHR of adolescent twins,while waist circumference is mainly effected by environmental factors.

关 键 词：青少年 双生研究 遗传 体型 

分 类 号：R174[医药卫生—妇幼卫生保健]