基质金属蛋白酶-2和p185^(HER-2/neu)蛋白在卵巢癌中的研究进展  

Research progress of MMP-2 and p185^(HER-2/neu) in ovarian cancer

作　　者：游牧[1,2] 刘文[1] 饶圣宏[3] 徐振山[4] 宋礼华[4] 

机构地区：[1]安徽医科大学生物化学与分子生物学教研室,合肥230032 [2]淮南联合大学医学系,淮南232001 [3]安徽大学生命科学学院,合肥230039 [4]安徽安科生物工程(集团)股份有限公司,合肥230088

出　　处：《生物学杂志》2011年第2期77-79,50,共4页Journal of Biology

基　　金：国家863项目(2004AA215860);安徽省教育厅自然科学基金(KJ2011B155);淮南联合大学产学研项目(NO.CYB1002)

摘　　要：基质金属蛋白酶-2(Matrix Metalloproteinase-2,MMP-2)是基质金属蛋白酶家族的重要成员,能降解明胶蛋白和Ⅳ型、V型胶原,在细胞外基质的降解过程中起着关键作用,能够促进肿瘤细胞发生侵袭和转移。p185HER-2/neu蛋白是一种相对分子质量185×103的跨膜糖蛋白,由HER-2/neu基因编码,属于酪氨酸激酶受体家族,p185HER-2/neu蛋白在人类多种癌症中存在扩增及过量表达,并与肿瘤的侵袭性表型及生存期短密切相关。就基质金属蛋白酶-2和p185HER-2/neu蛋白的生物学特性,与卵巢癌侵袭转移和预后的关系及MMP-2和p185HER-2/neu蛋白的研究情况等予以综述。Matrix metalloproteinase-2（MMP-2）,which is a member of MMPs family,can degrade glutin and collagen type Ⅳ and V.Matrix metalloproteinase-2 plays an important role in the course of degeneration of extracellular matrix and contributes to high invasiveness and metastasis of tumor cells.p185HER-2/ neu is a 185000 glycoprotein related to transmembrane tyrosine kinase receptor,which is encoded by the HER-2/ neu gene.The amplification or enhanced transcription of the p185HER-2/ neu is associated with the oncogenesis or increased severity of several types of cancers.This article summarized biological characters of MMP-2 and p185HER-2/ neu,their role in the invasion,metastasis and prognosis of ovarian cancer,and recent development in clinical application.

关 键 词：基质金属蛋白酶-2 p185HER-2/neu 卵巢癌 侵袭 预后 临床应用 

分 类 号：Q814.9[生物学—生物工程] R737.31[医药卫生—肿瘤]