亚甲蓝和纳米炭对子宫内膜癌前哨淋巴结的识别价值  

Sentinel lymph node indentification with methylene blue and activated carbon particles in endometrial cancer

作　　者：齐云平[1] 曲坚[1] 

机构地区：[1]济宁医学院附属医院,山东济宁272029

出　　处：《山东医药》2011年第13期21-23,共3页Shandong Medical Journal

基　　金：山东省医药科技发展计划项目(2009-QZ004)

摘　　要：目的探讨亚甲蓝和纳米炭混悬注射液作为淋巴示踪剂对子宫内膜癌前哨淋巴结(SLN)的识别价值。方法选择接受手术治疗的临床Ⅰ、Ⅱ期子宫内膜癌患者34例,随机分为两组。术中分别将亚甲蓝和纳米炭混悬注射液分多点注射于子宫浆膜下,追踪识别最先染色的淋巴结为SLN,随后行子宫切除及盆腔淋巴结清扫术。结果亚甲蓝组18例检出SLN者13例,共计47枚,其发现率为72%;SLN活检准确率为100%,假阴性率为0;有2例发生淋巴结转移,皆有SLN显示。纳米碳混悬液组16例检出SLN者12例,共计46枚,其发现率为75%;SLN活检准确率为100%,假阴性率为0;有1例发生淋巴结转移,且有SLN显示。两组以上检查结果比较均无统计学差异(P均>0.05)。未发现与本研究相关的损伤及不良反应。结论应用亚甲蓝、纳米碳混悬液在子宫内膜癌术中进行SLN识别均具有可行性。Objective To evaluate the identification value of methylene blue and activated carbon suspension injection which was as lymph tracer to sentinel lymph nodes （SLN） in endometrial cancer. Methods Thirty-four patients with clinical stage I-If endometrial cancer treated with operation were enrolled in the study. The patients were separated to two groups randomly. Methylene blue dye and activated carbon suspension injection were injected into the uterine subserosa in different point, tracing the first dyed node（ SLN）, then conducting hysterectomy and lymphadenectomy. Results Thirteen SLN cases were identified in blue dye group（ 18 cases）, sumping up to 47, the rate of finding was 72% ; the accurate rate of SLN biopsy was 100%, false negative rate was 0; two patients had nodal metastases and had showed SLN. Among activated carbon group, the SLNs were identified in 12 cases, anounting to 47, the rates of finding was 75% ; accuracy was 100 %, fake negative rate was 0. One patient had nodal metastases and showed SLN. There was no significant difference between the two groups（ P 〉 0.05 ）. No adverse reactions or injuries were found in the study. Conclusions Intraoperative SLN identification with methylene blue dye or activated carbon in endometrial cancer is feasible and safe.

关 键 词：子宫内膜肿瘤 前哨淋巴结活组织检查 亚甲蓝 纳米炭 

分 类 号：R737.33[医药卫生—肿瘤]