胎儿肾上腺分化发育和演变规律观察  

Development and Differentiation of Fetal Adrenal Gland

作　　者：高解春[1] 陈莲[1] 周丽君[1] 

机构地区：[1]上海医科大学儿科医院,200032

出　　处：《中华小儿外科杂志》1999年第4期218-219,共2页Chinese Journal of Pediatric Surgery

摘　　要：目的　观察胚胎肾上腺分化发育规律, 探讨神经母细胞瘤的发病原因和自然逆转。方法　胎龄8～44 周的15 例胚胎和18 例新生儿尸检标本, 观察分析不同胎龄肾上腺的神经母细胞结节数、最大面积和分布部位的变化。结果　神经母细胞结节自胚胎8 周起逐渐增多, 从皮质逐渐向髓质迁移; 胚胎15 ～18 周达高峰, 组织结构与原位神经母细胞瘤相似; 胚胎20 周以后结节逐渐减少、组织分化成熟, 偶有神经母细胞成分残留。结论　胚胎中期的肾上腺分化延滞可能是神经母细胞瘤发病原因,Objective The aim of this study searchs for the natural history of development of adrenal gland and its possible implication in the pathogenesis of neuroblastoma. Methods Neuronal cells and its area of distribution in adrenal glands from 15 fetuses of 8 to 44 week of gestation and 18 neonatal autopsies were examined. Results Neuronal cells started to increase in number from 8 week of gestation onwards, migrated from cortex to medulla and reached peak at 15 18th week of gestation. The histology of the neuronal cells at this stage resembled that of the neuroblastoma. The neuronal cells started to decrease in number and became more differentiated from 20th week onwards with occasional residual neuroblastoma like cells seen. Conclusion Aberration of embryonic neuronal cell differentiation may be related to the pathogenesis of neuroblastoma.

关 键 词：胚胎 肾上腺 分化 神经母细胞瘤 发育 

分 类 号：R739.402[医药卫生—肿瘤] R322.56[医药卫生—临床医学]