Snail mRNA与环氧化酶-2 mRNA在乳腺癌中的表达及临床意义  

The Expression and Clinical Significance of Snail mRNA and COX-2 mRNA in Breast Cancer

作　　者：熊正文[1] 李永申[1] 李伟[1] 胡海霞[1] 李宏伟[1] 

机构地区：[1]解放军251医院病理科,河北张家口075000

出　　处：《解放军医药杂志》2011年第2期1-5,I0001,共6页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：全军医学科学技术研究"十一五"计划课题(06MB085)

摘　　要：目的探讨Snail mRNA及环氧化酶-2(COX-2)mRNA在乳腺浸润性导管癌中的表达及其临床意义。方法应用原位杂交技术测定30例乳腺单纯性增生、30例乳腺导管内癌和70例乳腺浸润性导管癌组织中Snail mRNA及COX-2mRNA的表达。结果①Snail mRNA及COX-2 mRNA在乳腺单纯性增生、乳腺导管内癌和乳腺浸润性导管癌组织中的阳性率分别为23.3%、46.7%、81.4%和13.3%、63.3%、77.2%,组间差异有统计学意义(P<0.01);Snail mRNA及COX-2 mRNA在同组间表达差异无统计学意义(P>0.05)。②Snail mRNA及COX-2 mRNA表达均与乳腺浸润性导管癌淋巴结转移有关(P<0.05,P<0.01),与年龄、肿瘤大小和组织学分级无关(P>0.05)。③乳腺浸润性导管癌组织中Snail mRNA与COX-2mRNA表达呈显著正相关(r=0.53,P<0.01)。结论 Snail及COX-2在乳腺癌的发生、发展中起重要作用,检测二者的表达对判断乳腺癌的预后有重要价值。Objective To investigate the expressions of Snail mRNA and COX-2 mRNA in invasive ductal carcinoma and their clinical significance.Methods The expressions of Snail mRNA and COX-2 mRNA were detected on mammary gland hyperplasia（30 cases）,intraductal breast carcinoma（30 cases） and invasive ductal carcinoma（70 cases） by in situ hybridization.Results ①The positive expression rates of Snail mRNA and COX-2 mRNA in mammary gland hyperplasia,intraductal breast carcinoma and invasive ductal carcinoma respectively were 23.3%,46.7%,81.4% and 13.3%,63.3%,77.2%,and there were significant differences among them（P0.01）.But there were no differences between Snail mRNA and COX-2 mRNA in the same group（P0.05）.②Snail mRNA and COX-2 mRNA expressions were related to lymphatic metatasis（P0.05,P0.01）,but were not related to age,tumor size and histopathological grade（P0.05）.③There was a positive correlation between Snail mRNA and COX-2 mRNA in invasive ductal carcinoma tissues（r=0.53,P0.01）.Conclusion Snail mRNA and COX-2 mRNA may play an important role in the origin and development of breast carcinoma,and their expressions are of important diagnostic value in breast cancer prognosis.

关 键 词：乳腺肿瘤 SNAIL 环氧化酶-2 基因表达调控 肿瘤 原位杂交 

分 类 号：R737.9[医药卫生—肿瘤]