结节性甲状腺肿和甲状腺癌关系的临床研究  

Study of relation between nodular goiter and thyroid cancer

作　　者：刘池拽[1] 师天雄[1] 邓建伟[1] 孙世珺[2] 郑炳行[1] 杜鹃[2] 

机构地区：[1]中山市人民医院普外二科,广东中山528400 [2]中山市人民医院病理科,广东中山528400

出　　处：《中华普通外科学文献（电子版）》2011年第2期36-37,共2页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：目的探讨结节性甲状腺肿和甲状腺癌的关系。方法应用免疫组化法检测结节性甲状腺肿58例,结节性甲状腺肿伴增生结节15例,甲状腺癌44例,正常甲状腺组织20例标本中p27蛋白的表达。结果 p27蛋白表达阳性率在正常甲状腺组织为60.5%,结节性甲状腺肿为38.6%,甲状腺癌为34.1%,无结节性甲状腺肿伴增生结节,结节性甲状腺肿和甲状腺癌的p27蛋白表达阳性率明显高于结节性甲状腺肿伴增生结节的表达阳性率,均有显著性差异(P<0.01)。结论结节性甲状腺肿合并增生结节可能为癌前病变。Objective To study the relation between nodular goiter and thyroid cancer. Methods Immunohistochemical method was used to detect expression of p27 protein in 58 cases of nodular goiter, 15 cases of nodular goiter with hyperplastic nodule, 44 cases of thyroid cancer and 20 cases of normal thyroid tissue. Results The positive expression rate of p27 protein was 60.5% in normal thyroid tissue, 38.6% in nodular goiter, 34.1% in thyroid cancer and 0 in nodular goiter with hyperplastic nodule. The positive expression rate of p27 protein in both nodular goiter and thyroid cancer was significantly higher than this in nodular goiter with hyper- plastic nodule （P〈0.01）. Conclusions Nodular goiter with hyperplastic nodule may be a premalignant lesion, nodular goiter had malignant potential.

关 键 词：结节性甲状腺肿 增生结节 甲状腺癌 P27蛋白 

分 类 号：R736.1[医药卫生—肿瘤]