非小细胞肺癌中促红细胞生成素的表达及意义  

Expression Patterns of Erythropoietin in Non-small Cell Lung Cancer

作　　者：俞婷婷[1] 韩志刚[1] 单利[1] 

机构地区：[1]新疆医科大学附属肿瘤医院内一科,乌鲁木齐830011

出　　处：《医学综述》2011年第7期1094-1096,共3页Medical Recapitulate

基　　金：新疆维吾尔自治区自然科学基金(2010211A30)

摘　　要：目的探讨非小细胞肺癌(NSCLC)组织中促红细胞生成素(EPO)的表达情况。方法采用免疫组织化学法检测具有完整临床病理资料的58例未经治疗的NSCLC组织EPO的表达情况,以45例肺良性病变组织作为对照,分析EPO的表达水平与各临床病理因素的关系。结果 NSCLC组织中EPO的表达高于肺良性病变组织(P<0.05)。EPO的表达与患者年龄、吸烟史、pTNM分期、病理类型、组织分化程度及有无淋巴结转移无关(P>0.05)。结论 NSCLC患者高表达EPO,提示EPO可能参与了肿瘤的发生过程。Objective To study the expression patterns of erythropoietin（EPO） in non-small cell lung cancer（NSCLC）.Methods Fifty-eight patients who had complete clinicopathological data but were nave to any treatment were enrolled.The expression of EPO was examined by using the immunohistochemistry.Forty-five benign lung diseases were used to control for the analysis of EPO expression levels in relation to clinicopathological factors.Results The expression of EPO was significantly higher in NSCLC than that in benign disease（P0.05）.However,the expression of EPO was not associated with age,cigarette smoking history,pTNM stage,pathological type,histological differentiation,and lymph node involvement（P0.05）.Conclusion EPO is highly expressed in NSCLC,indicating the role of EPO in tumorigenesis.

关 键 词：非小细胞肺癌 促红细胞生成素 免疫组织化学 

分 类 号：R73[医药卫生—肿瘤]