肾上腺皮质激素治疗肝衰竭的疗效观察  

Adrenal Cortical Hormones for the Treatment of Hepatic Failure

作　　者：伍利军[1] 李海华[1] 刘锦华[2] 

机构地区：[1]陕西省汉中市传染病医院肝病科,陕西汉中723000 [2]上海市公共卫生临床中心,上海201508

出　　处：《医学综述》2011年第7期1110-1111,共2页Medical Recapitulate

摘　　要：目的探讨肾上腺皮质激素治疗肝衰竭的临床疗效。方法在综合治疗的基础上使用肾上腺皮质激素。开始3 d每日使用地塞米松10 mg静脉滴注,以后隔日1次注射地塞米松5 mg,待临床症状好转,总胆红素水平减退至患者最高峰值的一半以下时,改用地塞米松3～5 mg,间隔48～72 h一次,治疗组32例与对照组35例患者比较临床症状、生化指标好转情况及住院时间和费用情况。结果治疗组症状及生化指标好转率高于对照组,差异有统计学意义(P<0.05);两组并发症的发生率无统计学差异(P>0.05);治疗组患者的住院时间及费用低于对照组,差异有统计学意义(P<0.05)。结论激素冲击疗法治疗肝衰竭,疗程短、疗效/成本比高、不良反应少。Objective The effects of adrenal cortex hormones were observed in 67 patients with hepatic failure.Methods All patients received a multimodality therapy.Adrenal cortex hormones were given to in 32 patients（treatment group）,namely,intravenous dexamethasone（DXM） 10 mg/d at the first three days and 5 mg qod afterwards.When the clinical symptoms improved,and serum bilirubin decrease below the half of peak,DXM was given at a dose of 3～5 mg q48～72 h.In control group,35 patients received no cortical hormones.Results The rates of clinical symptom and liver function improvement in the treatment group were significantly higher than those in the control group（P0.05）.The incidences of complications in the two groups were comparable（P0.05）.The mean day of hospitalization in the treatment group was significantly shorter than that in the control group（P 0.05）.Conclusion Cortical hormone therapy is advantageous in shortening the course of treatment,high cost-effectiveness performance but with few side effects on patients with hepatic failure.

关 键 词：肾上腺皮质激素 肝衰竭 治疗 

分 类 号：R575.3[医药卫生—消化系统]