血小板活化和内皮细胞损害对大肠癌影响的临床研究  

The Study on the Activation of Platelet and Injury of Endothelial Cell Effects on Colorectal Cancer

作　　者：朱卫健[1] 王玫玫[1] 张爱华[1] 李小亮[1] 吴红[1] 孙达春[1] 

机构地区：[1]珠海市人民医院暨南大学医学院第三附属医院,珠海519000

出　　处：《血栓与止血学》2011年第2期66-68,72,共4页Chinese Journal of Thrombosis and Hemostasis

基　　金：广东省医学科学基金(A2000633)资助项目

摘　　要：目的研究血小板活化和内皮细胞损害对大肠癌病情和预后的影响。方法采用放射免疫法和酶联免疫法测定55例大肠癌和40例正常人血浆血栓烷B2(TXB2)、11-去氢-血栓烷B2(DH-TXB2)、血小板α-颗粒膜蛋白(GMP-140)、血管性血友病因子(vWF)、凝血酶调节蛋白(TM)、血清纤维结合蛋白(FN)和环磷酸乌苷(cGMP)含量。结果 (1)大肠癌TXB2、DH-TXB2、GMP-140、vWF、TM和cGMP升高,FN下降。(2)大肠癌cGMP与TXB2、DH-TXB2、GMP-140、TM之间均呈正相关。(3)合并感染TXB2、DH-TXB2升高,FN下降;已转移FN下降,其余指标升高;手术后FN升高,其余指标下降。结论大肠癌患者存在血小板活化和内皮细胞损害,二者影响大肠癌的转移和预后。Objective To study the effects of platelet activation and injury of endothelial cell on colorectal cancer patients and their prognoses.Methods Radio-immunity and ELISA were employed to detect the TXB2,DH-TXB2,GMP-140,vWF,TM,FN and cGMP level in 55 cases of colorectal cancer patients and 40 cases of normal,healthy control persons.Result（1）The levels of TXB2,DH-TXB2,GMP-140,vWF,TM（thrombomodulin） and cGMP increased,while FN（fibronectin） decreased in colorectal cancer.（2）cGMP was positively related to TXB2,DH-TXB2,GMP-140,TM in malignant tumor group.3.TXB2,DH-TXB2 increased,while FN decreased in colorectal cancer with infection;FN decreased in un-metastasis colorectal cancer,while the other indexes increased;FN increased,while the other indexes decreased after operation.Conclusion Activations of platelet and injuries of epithelium cells existed in colorectal cancer patients,and they affected the metastasis and prognosis of malignant tumor.

关 键 词：血小板活化 内皮细胞损害 大肠癌 

分 类 号：R735.34[医药卫生—肿瘤]