舍曲林合并阿立哌唑治疗难治性抑郁症对照研究  

A Randomized Controlled Trial of the Combination of Sertraline and Aripiprazole for Treatment-resistant Depression

作　　者：任兰振[1] 

机构地区：[1]中山大学附属东华医院心理科,广东东莞523100

出　　处：《中国医药指南》2011年第12期190-191,共2页Guide of China Medicine

摘　　要：目的探讨舍曲林联合阿立哌唑对难治性抑郁症的疗效。方法采用数字随机法将56例难治性抑郁症患者分为舍曲林合并阿立哌唑组(治疗组)和舍曲林合并安慰剂组(对照组),两组均为28例,观察时间为6周。主要疗效指标为汉密顿抑郁量表(HMAD)减分率,同时以症状量表(TESS)评定不良反应。结果治疗第6周末HAMD减分率舍曲林合并阿立哌唑组(58±6)%较舍曲林合并安慰剂组(38±5)%差异有统计学意义(t=10.85,P<0.01);治疗第4周开始治疗组评分明显低于对照组(P<0.01)。两组不良反应差异无统计学意义(P>0.05)。结论舍曲林联合阿立哌唑治疗难治性抑郁症的疗效优于舍曲林联合安慰剂。Objective To compare the efficacy of sertraline and aripiprazole combination sertraline for treatment-resistant depression.MethodA prospective stratified randomized controlled clinical trial were adopted to the patients with treatment-resistant depression.56 cases were divided into two groups with random number table,each group including 28 cases.One group was with combination aripiprazole,other with was combination placebo,for 6 weeks to observe the efficacy.The major indexes for therapeutic effects were Hamilton Depression Scale（HAMD） reducing score rate,with Symptom Scale（TESS） for unhealth at the same time.ResultsThe differences were significant in HAMD reducing score rate the group with sertraline combination aripiprazole（58？）% and the group with sertraline combination placebo（38？）%.The differences were not significant in unhealthy.ConclusionThe total efficcacy of sertraline combination aripiprazole is superior to sertraline combination placebo for treatment-resistant depression.

关 键 词：抑郁症 舍曲林 阿立哌唑 

分 类 号：R749.41[医药卫生—神经病学与精神病学]