人胃癌细胞系SGC-7901放射敏感性及异质性的研究  

Study about the Radiosensitivity and Heterogeneity of Human Gastric Cancer Cell Line (SGC 7901)

作　　者：苏颖[1] 沈世仁[1] 高频[1] 邹长 王衡[1] 汪相如[1] 

机构地区：[1]福建省肿瘤医院放射生物研究室

出　　处：《肿瘤防治研究》1999年第4期255-257,共3页Cancer Research on Prevention and Treatment

摘　　要：目的研究人胃癌细胞系ＳＧＣ７９０１及其克隆亚系的放射敏感性。方法ＳＧＣ７９０１细胞株及其两个克隆亚系（大集落、小集落）的细胞用８ＭｅＶ直线加速器电子束以不同剂量照射，分别经４８小时、７２小时培养及集落培养后，计数并得出各组存活曲线。结果１．两个克隆亚系之间的Ｄ０值有显著差异（Ｐ＜００５）；２．大集落亚系与ＳＧＣ母系之间在集落形成实验中，其Ｄ０值有差异（Ｐ＜００５）。结论ＳＧＣ７９０１细胞系及其克隆亚系对放射的敏感性存在着异质性。Objective To study the radiosensitivity of human gastric cancer cell line(SGC 7901) and two subcell lines picked from the line.Methods The cells of the cell line and two subcell lines (large clone and small clone) were radioted at different doses with 8 MeV linear accelerator.Then the cells were incubated for 48h,72h and clone culture.The survival curve was established by counting cell.Results (1) The values of Do between two subcell lines were significantly different( P <0 05);(2) the values of Do between large clone subcell line and SGC 7901 cell line were significantly different ( P <0 05).Conclusion Heterogeneity of the radiosensitivity among SGC 7901 and the subcell lines is suggested.

关 键 词：胃癌细胞系 SGC-7901 放射敏感性 异质性 

分 类 号：R735.205[医药卫生—肿瘤] R730.55[医药卫生—临床医学]