青春期鼻咽癌的放射治疗试析  

Analysis of 102 Nasophyrynageal Carcinoma(NPC) in the Age of Puberty

作　　者：廖玲霞[1] 李长青[1] 

机构地区：[1]湖北省肿瘤医院

出　　处：《肿瘤防治研究》1999年第4期303-304,共2页Cancer Research on Prevention and Treatment

摘　　要：目的本文回顾性分析青春期这一特殊年龄段鼻咽癌患者的特征及治疗效果，并涉及远期并发症。方法１９７５年７月至１９９２年１２月，我院收治１０２例青春期鼻咽癌，Ⅲ、Ⅳ期占８４３％（８６／１０２），全部接受放疗，其中６例Ｎ３患者接受化疗。结果全组局部控制率为７５９％（７８／１０２），１、３、５年生存率分别为８９９％（８６／１０２），６０７％（６２／１０２），５８６％（６０／１０２），Ⅲ、Ⅳａ期５年生存率为５２４％（３８／８６）。６例Ｎ３患者配合化疗３例存活５年以上。远期并发症包括不育和发育迟缓和继发性闭经。远处转移是主要死亡原因。结论尽管青春期鼻咽癌患者初诊时多为局部晚期，但经根治性放疗后获得良好疗效。联用化疗可能增加疗效。由于许多患者获长期生存，远期并发症影响生存质量的问题就显得格外突出。Abstract Objective To analysize retrospectively the characteristics of the teenagers with NPC.Methods 102 teenagers with NPC received external irradiation,among them,6 cases with N 3 diseases was treaed with chemotherapy simutaneously.The tumor dose of primary site was 38Gy～82Gy with an average dose of 66Gy.The number of patients with stage Ⅲ～Ⅳ was 86 which instituted 85% of the whole groupe.Reaults After a minimum follow up of 5 years,the overall 5 years survival rate was 58 6%.Administration of RT+CT to 6 cases with N 3 disease survived 3 cases.The main cause of deaths was remote metastases.Sterility and secondary amenorrhea was found in this group.Conclusion(1) Applications of chemotherpy may improve the suvives of patients with N 3 disease.(2) The protection of hypophysis of the youngs against irradiation should be emphasized.

关 键 词：鼻咽癌 放射疗法 青春期 并发症 

分 类 号：R739.630.5[医药卫生—肿瘤] R730.55[医药卫生—临床医学]