促红细胞生成素促脑血管新生机制研究进展  

The role of erythropoietin in regulating angiogenesis in brain

作　　者：祝慧凤[1] 徐晓玉[1] 万东[2] 张芬[1] 王红利[1] 薛莉君[1] 

机构地区：[1]西南大学药学院暨中医药学院,重庆400715 [2]重庆医科大学附属第一医院,重庆400016

出　　处：《中国药理学通报》2011年第4期451-454,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No81073084);西南大学博士基金资助项目(No104290-20710906)

摘　　要：促红细胞生成素(erythropoietin,EPO)是一种糖蛋白激素,是哺乳动物调节红细胞生成所必需的体液性生长因子。新近研究表明EPO具有神经保护和修复功能,其发挥脑保护效应有两条路径:即神经保护和血管新生。该文主要综述了EPO的血管新生效应和机制:EPO能够通过血脑屏障(BBB);EPO促进脑血管新生,效应与VEGF相当,但不增加BBB通透性;EPO动员骨髓内皮祖细胞到外周循环,促进内皮细胞增殖、迁移和管样结构形成,促进新生血管成熟为功能血管;EPO分泌具有可调控性。Erythropoietin,hormone produced by the kidney,plays a vital role in the formation of red blood cells by the bone marrow.However,recent studies indicate that EPO also has neuroprotective and repair functions of the brain;it has two paths：nerve protection and angiogenesis.In this paper,pro-angiogenesis effects and its mechanisms of EPO are reviewed：EPO can cross blood-brain barrier（BBB）;EPO and VEGF exhibit equal angiogenic potential,but prevents the increase in blood-brain barrier permeability induced by VEGF;EPO can promote endothelial progenitor from marrow to peripheral circulation and enhence endothelial cell proliferation,migration and blood vessel formation and maturation;EPO secretion can be induced.

关 键 词：促红细胞生成素 血脑屏障 脑血管新生 VEGF 效应 机制 可调控性 

分 类 号：R-05[医药卫生] R322.12