CT灌注成像联合磁共振扩散加权成像诊断急性脑梗死  

Combination of CT perfusion imaging and MR diffusion weight imaging in diagnosis of acute cerebral infarction

作　　者：朱建国[1] 杨亚芳[1] 刘斐[1] 唐继来[1] 沈世田[1] 田俊[1] 顾生荣[1] 万谦[1] 史永平[1] 朱成红[1] 

机构地区：[1]南京医科大学第二附属医院医学影像科,江苏南京210011

出　　处：《中国医学影像技术》2011年第4期710-713,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨联合应用CT灌注成像(CTPI)和MR DWI技术对急性脑梗死的临床诊断价值。方法对38例临床怀疑急性脑梗死的患者进行脑CTPI联合DWI检查,扫描结束后,经CT灌注软件和Funtiontool软件进行评估,统计各参数值。结果梗死脑区与对侧脑区比较,脑灌注(Perfusion)、强化峰值(PE)、达峰时间(TTP)、ADC值差异均有统计学意义(P均<0.05),脑血容量(CBV)差异无统计学意义(P>0.05);相对灌注值(rP)与相对CBV值(rCBV)具有显著相关性(r=0.721,P<0.05);rCBV与相对ADC值(rADC)具有相关性(r=0.476,P<0.05)。结论 CTPI各参数中,以TTP值和PE值的变化能最敏感地反映出急性梗死时血流动力学变化。rCBV与rADC共同反映梗死脑区的病理变化特征,具有本质上的相关性。Objective To observe the value of the combination of CT perfusion imaging（CTPI） and MRI DWI in diagnosis of acute cerebral infarction.Methods Totally 38 patients suspected of acute cerebral infarction were examined with CTPI and DWI.All data were evaluated with CTPI software and Funtiontool software.The parameters were statistically analyzed.Results Compared with contralateral brain regions,the value of Perfusion,perfusion enhance（PE）,time to peak（TTP） and ADC in the infarcted areas were significantly different（all P0.05）.Cerebral blood volume（CBV） value was not statistically different（P0.05）.There was significant correlation between relative perfusion（rP） and relative CBV（rCBV）（r=0.721,P0.05） as well as between rCBV and relative ADC（rADC）（r=0.476,P0.05）.Conclusion TTP and PE value reflect hemodynamic changes most sensitively among all the CTPI parameters during acute infarction.Being naturally related,rCBV and rADC together describe the pathological changes of acute cerebral infarction.

关 键 词：灌注成像 扩散磁共振成像 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]