正常成年SD大鼠明视闪光视网膜电图特征  

The Photopic Electroretinogram in Normal Adult SD Rat

作　　者：陈红玲[1] 刘丽芳[1] 林洪杰[1] 耿义群[1] 张铭志[1] 

机构地区：[1]汕头大学.香港中文大学联合汕头国际眼科中心,汕头515041

出　　处：《Eye Science》2010年第2期103-106,共4页眼科学报（英文版）

基　　金：广东省医学科研基金资助项目(B2008139)

摘　　要：目的:探讨正常成年SD大鼠的明视视网膜电图(Electroretinogram,ERG)特征。方法:选取正常9～12周SD大鼠60只,使用罗兰视觉电生理仪记录大鼠右眼的明视闪光ERG。使用SPSS统计分析a波、b波和明视负波反应(Photopicnegativeresponse,PhNR)的隐含期和振幅。比较雄性和雌性SD大鼠明视ERG特征。结果:每只SD大鼠均能记录到稳定的a波、b波和PhNR,其中a波的隐含期和PhNR的隐含期及振幅均符合正态分布,而其余指标均不符合正态分布。PhNR的隐含期为124.6±8.5ms,其变异系数最小(0.07)。PhNR的振幅为(11.3±4.2)μV,变异系数为0.37。雄性和雌性SD大鼠明视ERG的各反应波之间无显著差异。结论:在正常成年SD大鼠,明视闪光ERG是一项客观评价大鼠明视状态下视网膜功能的手段,PhNR可以作为一项稳定的评价内层视网膜功能的指标。Purpose： To study the characteristics of photopic flash electroretinogram （ERG） in normal adult SD rats. Methods： Sixty normal adult SD rats aged 9 to 12 weeks old were enrolled in this study. Photopic flash ERG were recorded from these 60 SD rats. The results were analyzed with SPSS. Results： Stable a, b and PhNR wave could be recorded in each rat. Implicit time of a wave,implicit time and amplitude of PhNR fit normal distribution. Implicit time of PhNR was （124.6±8.5）ms with the smallest coefficient of variation of 0.07. The amplitude of PhNR was （11.3±4.2）μV and coefficient of variation was 0.37. There was no difference between the results of female and male rats. Conclusion： Photopic flash ERG is an objective method in evaluating the retinal function in rats and PhNR can be used as a sensitive index of inner retinal function.

关 键 词：视网膜电图 大鼠 

分 类 号：R774[医药卫生—眼科]