帕金森病与快动眼睡眠行为障碍  

Parkinson's Disease and Rapid-eye-movement Behavior Disorder

作　　者：喻哲明[1] 丁正同[1] 

机构地区：[1]复旦大学附属华山医院神经内科,200040

出　　处：《中国临床神经科学》2011年第2期203-208,共6页Chinese Journal of Clinical Neurosciences

摘　　要：快动眼期睡眠行为障碍(RBD)是以REM期睡眠肌肉失张力的消失、伴随梦境发生的暴力行为等为特点,患者常会伤及他人和自身。RBD与帕金森病(PD)密切相关,伴有RBD的PD与不伴有RBD的PD有着不同的发病模式。在少动-强直型PD患者,RBD可在PD典型症状出现之前发生。RBD在经颅脑超声信号、脑电图、脑血流灌注、多巴胺代谢等方面的异常表现越来越支持RBD可能是PD发病的一个阶段。多数患者对氯硝西泮治疗有效。The rapid-eye-movement behavior disorder（RBD） is characterized by loss of muscular atonia and violent behavior when dreaming,which would often injure the patient or bed partner.RBD is quite associated with Parkinson＇s disease（PD）,PD with RBD may result in a different underlying pathophysiologic pattern compared with PD without RBD.In some cases,the RBD may precede the typical motor symptoms of PD.The strong association between RBD and the abnormalities of transcranial sonography, electroencephalographic,cerebral blood flow and the metabolization of dopamine may support the assumption that RBD might be a stage of the process of the PD.Most of the cases respond to clonazepam.

关 键 词：快动眼睡眠行为障碍 帕金森病 机制 治疗 

分 类 号：R742.5[医药卫生—神经病学与精神病学]