肺癌的MR全身DWI与PET成像的对照研究  

Comparison of whole-body diffusion-weighted magnetic resonance imaging and positron emission tomography in lung cancer

作　　者：康厚艺[1] 张伟国[1] 金榕兵[2] 陈金华[1] 

机构地区：[1]第三军医大学附属医院野战外科研究所放射科,重庆400042 [2]第三军医大学附属医院野战外科研究所核医学科,重庆400042

出　　处：《放射学实践》2011年第3期286-289,共4页Radiologic Practice

摘　　要：目的:探讨MR DWI及PET成像在肺癌诊断及鉴别诊断中的应用价值。方法:26例临床高度怀疑为肺癌且接受了PET检查的患者行MR DWI检查,通过三维图像重组及黑白翻转技术,得到"类PET"图像,观察病变的形态、大小和分布,并与PET影像进行比较,在工作站上测量肺部病变的ADC值及SUV值,进行相关性分析。最终的诊断结果依据影像学检查、病理诊断和随访复查共同确定,其中肺癌19例,肺部炎性假瘤1例,慢性炎症4例,淋巴结反应性增生2例。结果:以病理结果为金标准,PET检出肺癌的敏感度为100%,特异度为57.1%;MR DWI的敏感度为94.7%,特异度为71.2%。肺癌与炎性病变的ADC值及SUV值差异均有统计学意义(P<0.01),肺癌病灶的ADC值与SUV值没有明显线性相关关系(r=-0.293,P>0.05)。结论:MR DWI及PET成像对肺癌的诊断有较高的敏感度及特异度,两种方法互为补充,可为肺癌的诊断及鉴别诊断提供更多的信息。Objective：To compare the clinical application of whole-body DWI and PET in the diagnosis and differential diagnosis for lung cancer patients.Methods：26 patients who had been highly suspected of lung cancer and had undergone PET underwent whole-body DWI（19 cases of lung cancer,1 of inflammatory pseudotumor,4 of chronic inflammation and 2 of reactive hyperplasia of lymph node）.All native axial images were reformatted by 3D-MIP and the grey scale was subsequently inverted against to obtain ＂similar to PET＂ images.The appearance,size and distribution of lesions were observed and compared with those of PET.The definitive diagnosis was confirmed with radiological,pathological and follow-up evidences.The ADC and SUV values of pulmonary lesions were measured and the correlations of them were analysed statistically.Results：Taking pathology results as the gold standard,the sensitivity and specificity of PET on the diagnosis of lung cancer lesions as 100% and 57.1%,the sensitivity and specificity of whole-body DWI were 94.7% and 71.2%.The differences of both of the ADC and SUV values between lung cancer lesion and inflammatory disease were significant（P0.01）.There was no significant linear correlation between the ADC and SUV values of lung cancer lesions（P0.05）.Conclusion：Whole-body DWI and PET have a high sensitivity and specificity on the diagnosis of lung cancer lesions,they can complement each other for providing more information for the diagnosis and differential diagnosis of lung cancer lesions.

关 键 词：肺部病变 扩散加权成像 正电子发射体层摄影术 

分 类 号：R734.2[医药卫生—肿瘤]