甲状腺相关眼病患者97例回顾性分析  

Retrospective analysis of 97 cases with thyroid-associated ophthalmopathy

作　　者：刘芳 朱豫[2] 

机构地区：[1]市中心医院眼科, 河南省驻马店 463000 [2]郑州大学第一附属医院眼科, 河南省郑州市450052,

出　　处：《眼科新进展》2011年第4期373-375,共3页Recent Advances in Ophthalmology

基　　金：河南省2008年科技攻关项目(编号:082102310049)~~

摘　　要：目的探讨甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)的临床特征、病情特点及影响因素,为临床早期诊断和治疗提供依据。方法对我院2007年1月至2009年12月诊治的97例(171眼)TAO患者的临床资料进行回顾性分析。结果 97例TAO患者平均发病年龄(44.6±12.8)岁,女性多见,多为双眼发病,以眼球突出为主要就诊原因。78例(144眼)患者伴有甲状腺功能异常。眼睑退缩127眼(73.2%),上睑迟落116眼(63.9%),闭合不全54眼(33.0%),眼睑肿胀76眼(42.3%),球结膜充血及水肿65眼(37.1%);眼球突出119眼(70.1%),眼球运动受限116眼(69.1%),CT测量眼外肌肥厚132眼(77.2%),下直肌受累124眼(72.5%),眼压增高34眼(27.8%),视神经病变21眼(13.4%)。结论 TAO的发病多伴甲状腺功能的异常,其临床特征有其自身的特点,早期正确的临床诊断及病情分析对疾病的治疗有重要意义。Objective To investigate the clinical characteristics,pathogenetic condition and influencing factors of thyroid-associated ophthalmopathy（TAO） and provide evidence for diagnosis and treatment at early clinical stage. Methods Retrospective analysis was taken in 97 cases（171 eyes） with TAO from January 2007 to December 2009. Results The average age of onset of 97 cases with TAO was（44.6±12.8） years old.Female patients and binocular disease were common.The main reason for visiting doctor was exophthalmos.There were 78 cases with abnormal thyroid function.There were 127 eyes（73.2%） with eyelid retraction,116 eyes（63.9%） with delayed shed of palpebra frontalis,54 eyes（33.0%） with dysraphism,76 eyes（42.3%） with eyelid engorgement,65 eyes（37.1%） with conjunctival hyperemia and edema,119 eyes（70.1%） with exophthalmos,and 116 eyes（69.1%） with ocular limitation of movement.CT showed that there were 132 eyes（77.2%） with extraocular muscle hypertrophy,and 124 eyes（72.5%） were most commonly involved in inferior rectus;There were 34 eyes（27.8%） with high intraocular pressure,21 eyes（13.4%） with optical neuropathy. Conclusions The morbidity of TAO is mostly related to abnormal thyroid function,and the clinical manifestation has its own characteristics.Early accurate diagnosis and analysis of pathogenetic condition are essential for the treatment of disease.

关 键 词：甲状腺相关眼病 眼球突出 眼压 视神经病变 

分 类 号：R777.2[医药卫生—眼科]