Advancement and prospects of tumor gene therapy  

作　　者：Chao Zhang Qing-Tao Wang He Liu Zhen-Zhu Zhang Wen-Lin Huang 

机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China [2]State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China [3]Research Department, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China.

出　　处：《Chinese Journal of Cancer》2011年第3期182-188,共7页

基　　金：supported by Foundation from Knowl edge Innovation Program in CAS (No. KSCX1-YW-R-10);National Natural Science Foundation of China(No. 30973448)

摘　　要：Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based (tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes) and RNA-based (antisense oligonucleotides and RNA interference) approaches. In addition, immune response-based strategies (dendritic cell- and T cell-based therapy) are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based （tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes） and RNA-based （antisense oligonucleotides and RNA interference） approaches. In addition, immune response-based strategies （dendritic cell- and T cell-based therapy） are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.

关 键 词：肿瘤基因治疗 非病毒载体 RNA干扰 肿瘤抑制基因 反义寡核苷酸 抗血管生成 树突状细胞 肿瘤治疗 

分 类 号：Q782[生物学—分子生物学] Q522