卡培他滨联合顺铂治疗晚期头颈部鳞癌的疗效观察  

Capecitabine Plus Cisplatin for Advanced Squamous Cell Cancer of Head and Neck

作　　者：符炜[1] 钱屹崟[1] 陆屸 

机构地区：[1]江苏省常熟市第一人民医院肿瘤科,常熟市215500

出　　处：《医药论坛杂志》2010年第24期21-22,共2页Journal of Medical Forum

摘　　要：目的观察卡培他滨联合顺铂方案(XP)治疗晚期头颈部鳞癌的疗效及不良反应,并与5-氟尿嘧啶联合顺铂方案(FP)作随机对照。方法 XP组35例患者:卡培他滨,2500mg/(㎡.d),分两次口服,餐后30min,第1～14d,顺铂20 mg/㎡,静脉滴注,第1～4d。FP组37例患者:5-FU 750mg/(㎡·d),CIV9,6h,第1～4d,顺铂20 mg/㎡,静脉滴注,第1～4d。以上方案均为21天重复。结果 XP组和FP组的有效率为57.1%和54.1%(P>0.05);中位OS为16.5和15.8月(P>0.05)。XP组III-IV度粒细胞减少,恶心呕吐,腹泻和口腔炎发生率明显低于FP组。结论 XP和FP均为治疗晚期头颈部鳞癌的较好的化疗方案,XP方案毒副作用小,治疗耐受性好。Objective To compare the clinical efficacy and toxicity of capecitabine plus cisplatin versus 5-fluorouracie plus cisplatin in treatment of adavanced squamous cell cancer of the head and neck. Methods Thirty-five cases were treated with Xp regimen and the other thirty-seven cases were treated with FP regimen,both regimens were repeated every three weeks. Results The results showed no significant difference in response rate and overall survival rate between the two regimens. Conclusion These results showed that the two regimens both are effective and tolerable.

关 键 词：晚期头颈部鳞癌 卡培他滨 顺铂 联合化疗 

分 类 号：R739.91[医药卫生—肿瘤]