红花五味子中四个新的联苯环辛二烯类木脂素(英文)  

Four New Dibenzocyclooctadiene Lignans from Schisandra rubriflora

作　　者：罗晓[1] 普建新[1] 范鹏[2] 石一鸣[1] 杨光宇[1] 李小年[1] 雷春[1] 高雪梅[1] 张海波[1] 肖伟烈[1] 孙汉董[1] 

机构地区：[1]中科院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,昆明650204 [2]云南民族大学化学与生物技术学院,昆明650031

出　　处：《中国天然药物》2011年第3期167-172,共6页

基　　金：supported by the NSFC (Nos. 30830115 and 20802082);the Major State Basic Research Development Program of China (Nos. 2009CB522300 and 2009CB940900);the Young Academic and Technical Leader Rising Foundation of Yunnan Province (2006PY01-47);the Drug Development from Five Medicinal Plants in West China and their Sustainable Uses (KZCX2-XB2-15);fund from CAS (KSCX2-EW-Q-10)~~

摘　　要：目的:研究湖北恩施地区产红花五味子茎干的化学成分。方法:采用硅胶和RP-18等层析柱分离手段以及半制备和制备高效液相,运用2D-NMR,HR-ESI-MS以及圆二色谱等波谱技术鉴定化合物的结构。结果:从红花五味子中分离鉴定出4个新的联苯环辛二烯类木脂素并命名为schirubrisinsA-D(1-4),另外还有14个已知化合物。结论:化合物1-4是新的联苯环辛二烯类木脂素。AIM： To study the chemical constituents of the stems of Schisandra rubriflora （Franch.） Rehd. et Wils collected from Enshi, Hubei Province, China. METHODS： Compounds were isolated by column chromatography with silica gel, RP-18 gel, and semi-preparative and preparative HPLC. Their structures were elucidated by extensive spectroscopic methods, including 2D-NMR, HR-ESI-MS and CD techniques. RESULTS： Four new dibenzocyclooctadiene lignans, schirubrisins A-D （1-4）, together with fourteen known ones （5-18） were isolated from the stems of S. rubriflora. CONCLUSION： Compounds 1-4 are new dibenzocyclooctadiene lignans.

关 键 词：红花五味子 化学成分 联苯环辛二烯类木脂素 

分 类 号：R284[医药卫生—中药学]