supported by the NSFC (Nos. 30830115 and 20802082);the Major State Basic Research Development Program of China (Nos. 2009CB522300 and 2009CB940900);the Young Academic and Technical Leader Rising Foundation of Yunnan Province (2006PY01-47);the Drug Development from Five Medicinal Plants in West China and their Sustainable Uses (KZCX2-XB2-15);fund from CAS (KSCX2-EW-Q-10)~~