c-src和c-met与甲状腺乳头状癌淋巴结转移的关系  

Correlation between the expressions of c-src and c-met in papillary thyroid cancer and lymph node metastasis

作　　者：王丽[1] 刘泽兵[1] 罗金芳[1] 董军明[1] 

机构地区：[1]复旦大学附属金山医院病理科,上海200540

出　　处：《复旦学报（医学版）》2011年第2期131-135,共5页Fudan University Journal of Medical Sciences

摘　　要：目的探讨c-src和c-met在甲状腺乳头状癌(thyroid papillary cancer,TPC)中的表达及其与TPC淋巴结转移的关系。方法免疫组化EnVision法检测35例TPC切除标本中c-src和c-met的表达,并分析表达情况与淋巴结转移等临床病理指标之间的关系;同样方法检测16例TPC原发性TPC和淋巴结转移性TPC中c-src和c-met的表达,并进行比较。结果 c-src和c-met在TPC中的表达阳性率分别为62.9%和97.1%,与其在甲状腺良性病变组织中表达的差异均有统计学意义(P=0.000 4,P<0.001)。c-src在TPC组织中的表达与肿瘤大小和淋巴结转移相关(P=0.000 2,P=0.001 7);c-met在TPC组织中的表达与患者年龄相关(P=0.015 5)。TPC中c-src和c-met的表达呈正相关。c-src和c-met在淋巴结转移性癌中的表达阳性率均高于原发性癌,但两者在原发性癌中的表达与淋巴结转移性癌中表达的差异无统计学意义。结论 c-src和c-met的异常表达在TPC的发生发展中起重要作用,并且可能与TPC的淋巴结转移有关。Objective To evaluate the expressions of c-src and c-met in thyroid papillary cancer（TPC） and to investigate their associations with lymph node metastasis. Methods The expressions of c-src and c-met were evaluated by immunohistochemistry in 35 cases of TPC,and their associations with clinicalpathological characters were analyzed.The expressions of c-src and c-met in 16 cases of primary carcinoma and metastatic carcinoma were evaluated by the same method. Results The positive rates of c-src and c-met in 35 cases of TPC were 62.9% and 97.1%.They had statistical differences compared with benign tissues（P=0.000 4,P0.001）.The expression of c-src in tumor tissues was associated with tumor grade and lymph node metastasis（P=0.000 2,P=0.001 7）,and the association between c-met expression and patient age was also found（P=0.015 5）.The positive expression of c-src closely related to the expression of c-met,The positive rates of c-src and c-met in metastatic carcinoma were higher than those in primary carcinoma（93.8%）,but there was no statistical difference between the expressions of c-src and c-met in primary carcinoma and metastatic carcinoma. Conclusions The abnormal expressions of c-src and c-met might play an important role in the growth and invasion of TPC,and might have some relationship with lymph node metastasis.

关 键 词：C-SRC C-MET 甲状腺乳头状癌 淋巴结转移 免疫组化 

分 类 号：R736.1[医药卫生—肿瘤]