微血管密度在结直肠癌中的表达及意义  

The expression of microvessel density in colorectal cancer and its significance

作　　者：苏亦斌[1] 吴伟岗[1] 陈国宝[1] 

机构地区：[1]福建医科大学附属泉州第一医院普外科,福建泉州362000

出　　处：《临床肿瘤学杂志》2011年第3期236-238,共3页Chinese Clinical Oncology

摘　　要：目的探讨微血管密度(MVD)在结直肠癌中的表达及其与肿瘤血管生成、临床病理因素和预后的关系。方法用免疫组化SP法检测80例结直肠癌、30例结直肠腺瘤及30例正常结直肠组织中CD34表达并计算MVD值,分析MVD值与结直肠癌临床病理因素及预后的关系。结果结直肠癌MVD值为30.2±6.3,显著高于结直肠腺瘤的13.1±1.6和正常结直肠组织的6.5±2.7,差异均有统计学意义(P<0.01)。结直肠癌MVD值与Dukes分期、肿瘤浸润深度、淋巴结转移显著相关(P<0.01)。结直肠癌高MVD值组患者5年生存率为35.71%,显著低于低MVD值组的71.05%,差异有统计学意义(P<0.01)。结论 MVD值在结直肠癌中较高,并能够预示肿瘤具有更高的侵袭性及不良预后。Objective To study the expression of microvessel density（MVD） in colorectal cancer and its relationship with tumor angiogenesis,clinicopathologic features and prognosis. MethodsImmunohistochemical technique was used to detect the expression of MVD in 80 cases of colorectal cancer,30 cases of colorectal adenoma and 30 cases of normal colorectal tissues.The relationship between the expression of MVD and tumor clinicopathologic feature,prognosis of patients was analyzed. ResultsThe MVD of colorectal cancer（30.2±6.3） was significantly higher than that of colorectal adenoma（13.1±1.6）and normal colorectal tissue（6.5±2.7）.The MVD of colorectal cancer was correlated with Dukes stage,invasive depth and lymphnode metastasis（P0.01）.In colorectal cancer patients,the 5-year survival rate in the high MVD group（35.71%） was significantly lower than that in the low MVD group（71.05%）. ConclusionThere is overexpression of MVD in colorectal cancer,which may lead to advanced invasion of tumor and unfavorable prognosis.

关 键 词：结直肠癌 微血管密度(MVD) 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]