胃运动和感觉功能在符合罗马Ⅲ标准的功能性消化不良患者中的特点  

Gastric motor and sensory function in patients with functional dyspepsia diagnosed based on the Rome Ⅲ Criteria

作　　者：吴改玲[1] 蓝宇[1] 王玘[1] 闫冰[2] 张小晋[1] 

机构地区：[1]北京积水潭医院消化内科,北京市100035 [2]北京积水潭医院超声科,北京市100035

出　　处：《世界华人消化杂志》2011年第7期734-738,共5页World Chinese Journal of Digestology

摘　　要：目的:研究符合罗马Ⅲ标准的功能性消化不良(FD)患者的胃运动和感觉功能的特点以及不同类型的FD患者病理生理机制的差异.方法:对符合罗马Ⅲ标准的44例FD患者根据罗马Ⅲ分类标准分为餐后不适综合征(PDS,31例)和上腹痛综合征(EPS,13例)两个类型,10例无症状的健康人作为对照组,对所有受试者均进行上胃肠消化不良症状评分、5h胃排空检查、水负荷试验.结果:FD、PDS患者胃排空率较对照组明显减低(57.74%±5.56%,52.26%±8.12%vs84.00%±5.76%,P=0.015,P=0.003),PDS患者胃排空率较EPS有减低趋势(56.26%±8.12%vs68.08%±9.86%,P<0.05).FD、PDS患者的胃感知饮水量和最大饱足饮水量较对照组明显减少(567.61mL±25.22mL,548.23mL±29.36mLvs725.00mL±54.90mL,P=0.006,P=0.01;917.16mL±39.44mL,894.17mL±47.65mLvs1240.00mL±75.57mL,P=0.000,P=0.001).PDS的胃感知饮水量和最大饱足饮水量较EPS有减少趋势.EPS的最大饱足饮水量较对照组明显减少(P=0.025).结论:FD患者存在胃排空和近端胃感觉功能的异常,PDS患者胃排空延迟和近端胃扩张功能及顺应性受损更为明显.AIM：To investigate the changes in gastric motor and sensory function in patients with functional dyspepsia（FD） diagnosed based on the Rome Ⅲ Criteria.METHODS：Forty-four FD patients who were diagnosed according to the Rome Ⅲ Criteria and 10 healthy volunteers were enrolled in this study.FD patients were divided into postprandial distress syndrome（PDS） group（n = 31） and epigastric pain syndrome（EPS） group（n = 13）.Ten healthy subjects（HS） were used as controls.Epigastric discomfort scoring,gastric emptying test,and water load test were performed in all participants.RESULTS：The rate of gastric emptying was sig-nif icantly lower in FD patients and PDS patients than in HS（57.74% ± 5.56%,56.26% ± 8.12% vs 84.00% ± 5.76%,both P 0.01）.The rate of gastric emptying of the PDS group was significantly lower than that of the EPS group（56.26% ± 8.12% vs 68.08% ± 9.86%,P 0.05）.The threshold volume and satiety volume of drinking water were significantly lower in FD patients than in HS（567.61 mL ± 25.22 mL vs 725.00 mL ± 54.90 mL,917.16 mL ± 39.14 mL vs 1 240.00 mL ± 75.57 mL,P = 0.01,0.001）,and in PDS patients than in HS（P = 0.006,0.000） and EPS patients（both P 0.05.The satiety volume was signif icantly lower in EPS patients than in HS（P = 0.025）.CONCLUSION：Abnormalities of gastric motor and sensory function are common in FD patients.Delayed gastric emptying,and abnormality of proximal gastric relaxation and compliance in PDS patients are more serious than those in EPS patients.

关 键 词：罗马Ⅲ标准 功能性消化不良 胃排空 水负荷试验 

分 类 号：R57[医药卫生—消化系统]