卵巢癌患者血浆TM及EPCR检测的临床意义  

Predictive value of thrombomodulin and endothelial cell protein C receptor levels in patients with ovarian cancer

作　　者：胡敏[1] 荣红[2] 

机构地区：[1]海南医学院附属医院血液科,海南海口570102 [2]海南医学院附属医院口腔科,海南海口570102

出　　处：《海南医学院学报》2011年第3期320-322,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020110063)~~

摘　　要：目的:检测卵巢癌患者血浆血栓调节蛋白(TM)和血管内皮细胞蛋白C受体(EPCR)的水平,探讨其临床意义。方法:采用酶联免疫吸附(ELISA)法检测卵巢癌患者35例、卵巢良性肿瘤患者28例,健康体检妇女70例血浆TM、EPCR的含量。结果:91.4%(32/35)卵巢癌患者血浆TM明显升高,与对照组相比差异有统计学意义(P<0.01);与良性肿瘤患者相比差异有统计学意义(P<0.05)。21.4%(6/28)良性肿瘤患者轻度升高,与对照组相比差异无统计学意义(P>0.05)。80.0%(28/35)卵巢癌患者血浆EPCR明显升高,与对照组相比差异有统计学意义(P<0.01);与良性肿瘤患者相比差异有统计学意义(P<0.05)。17.6%(5/28)良性肿瘤患者轻度升高,与对照组相比差异无统计学意义(P>0.05)。结论:早期检测血浆TM、EPCR的含量,有利于为肿瘤的临床诊断和治疗提供新的思路和帮助。Objective：To determine the plasma of thrombomodulin（TM） and endothelial cell protein C receptor（EPCR） levels in patients with ovarian cancer in order to explore their clinical significance.Methods：The levels of TM and EPCR were detected in 35 ovarian cancer patients,28 cases of benign ovarian tumor,as well as 70 healthy control volunteers by ELISA.Results：91.4% patients with ovarian cancer showed significant higher TM levels comparing with patients with benign tumors（P0.05） or healthy control group（P0.01）.21.4% patients with benign tumors showed slightly increased TM with no significant difference comparing with the control group（P0.05）.80.0% patients with ovarian cancer showed significantly increased EPCR levels compared with patients with benign tumors（P0.05） or healthy control group（P0.01）,EPCR level also slightly increased in patients with benign tumors but there was no significant difference was shown comparing with the control group（P0.05）.Conclusions：Detection of Tm and EPCR level is helpful for the early diagnosis and treatment of ovarian cancer.

关 键 词：卵巢癌 血栓调节蛋白 血管内皮细胞蛋白C受体 

分 类 号：R737.31[医药卫生—肿瘤]