Preparation technology of Naoxueling capsules  

作　　者：Li-qun Kang Bo Li Jia-gen Wen Ying He Qi-lu Wang Hui-ying Li Yu-xiang Chen 

机构地区：[1]School of Pharmacy, Central South University, Changsha, Hunan 410013, P.R.China [2]School of Biological Science and Technology, Central South University, Changsha, Human 410013, P.R.China

出　　处：《中国现代医学杂志》2011年第6期733-742,共10页China Journal of Modern Medicine

基　　金：Hunan Natural Science Foundation (2009FJ3209);Changsha Science and Technology Plan (K0902033-31)

摘　　要：Objective To optimize the preparation of the Naoxueling capsules.Methods To optimize the extraction of the Naoxueling prescription successively with alcohol and water,several principal ingredients in the final extracts were evaluated and data were analyzed by the orthogonal test.The capsule-molding process was investigated by measuring the angle of repose and the moisture absorption percentage.Results The optimum process of the alcohol extraction was the refluxing of herbs first in twelve-fold volume of 75% ethanol for 2 h,then in eight-fold volume of 75% ethanol for 1.5 h,and finally in seven-fold volume of 75% ethanol for 0.5 h.Meanwhile,the best water extraction was performed by boiling samples in twelve-fold amount of water for 2 h followed by another 1 h in eight-fold amount of water.To mold the capsule,the appropriate ratio of micro-powder to dextrin was 20:1.Conclusion The preparation technology of the Naoxueling capsules is reasonable and feasible,which provides evidences for the industrial manufacture.Objective To optimize the preparation of the Naoxueling capsules. Methods To optimize the extraction of the Naoxueling prescription successively with alcohol and water, several principal ingredients in the final extracts were evaluated and data were analyzed by the orthogonal test. The capsule-molding process was investigated by measuring the angle of repose and the moisture absorption percentage. Results The optimum process of the alcohol extraction was the refluxing of herbs first in twelve-fold volume of 75% ethanol for 2 h, then in eight-fold volume of 75% ethanol for 1.5 h, and finally in seven-fold volume of 75% ethanol for 0.5 h. Meanwhile, the best water extraction was performed by boiling samples in twelve-fold amount of water for 2 h followed by another 1 h in eight-fold amount of water. To mold the capsule, the appropriate ratio of micro-powder to dextrin was 20 ： 1. Conclusion The preparation technology of the Naoxueling capsules is reasonable and feasible, which provides evidences for the industrial manufacture.

关 键 词：Naoxueling capsule EXTRACTION total flavones tanshinone ⅡA ASTRAGALOSIDE 

分 类 号：R944.5[医药卫生—药剂学]