ASTRAGALOSIDE

作品数：30被引量：193H指数：9
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相关领域：医药卫生更多>>
相关作者：潘艳芳贾晓涛曹倩李自普彭小忠更多>>
相关机构：中国医学科学院基础医学研究所约克大学陕西中医药大学青岛大学医学院附属医院更多>>
相关期刊：《Chinese Herbal Medicines》《Medicinal Plant》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金河南省自然科学基金上海市科学技术委员会基础研究重点项目山西省卫生厅科技攻关计划项目更多>>
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Astragaloside in cancer chemoprevention and therapy被引量：3
《Chinese Medical Journal》2023年第10期1144-1154,共11页Yaning Wang Zhuo Zhang Zhaohua Cheng Wei Xie Hanjiao Qin Jiyao Sheng 
Natural Science Foundation of China(Nos.81902484,82002809);China Postdoctoral Science Foundation(No.2020M670864);Jilin Province young health scientist training program(No.2020Q017);Medical and Health Talents Project of Jilin Province(Nos.2020SCZT039,2020SCZT097);Youth Support Project of Jilin Association for Science and Technology(No.202028);Jilin Province Science and Technology Development Plan(No.20210204028YY)
Tumor chemoprevention and treatment are two approaches aimed at improving the survival of patients with cancers.An ideal anti-tumor drug is that which not only kills tumor cells but also alleviates tumor-causing risk ...
关键词：ASTRAGALOSIDE CARCINOMA CHEMOPREVENTION ANTI-TUMOR Tumor recurrence 
AstragalosideⅣameliorates insulin induced insulin resistance in HepG2 cells through reactive oxygen species mediated c-Jun N-terminal kinase pathway被引量：1
《Journal of Traditional Chinese Medicine》2023年第1期60-67,共8页YE Xiaomei XING Xiaowei YUAN Kangrui WANG Dongming WU Dudu CHEN Zhi YU Zhiqiang 
Supported by National Natural Science Foundation of Guangdong Province(No.2017A030310666,No.2018A030307003);Guangdong Medical University Nanhai Marine Biomedical Resources R&D Public Service Platform Open Fund Project(No.2HC18013 and No.2HC18016);“Group-type”Special Support Project for Education Talents in Universities(No.4SG19045G);Undergraduate Science&Technology Innovation Foundation of Guangdong Province(No.201810571046,No.201810571073);Medical Science and Technology Development Foundation of Guangdong Province(No.A2016355);the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University)(Grant No.sklpme2018-4-23)。
OBJECTIVE:To investigate the effects and elucidate the mechanism of Astragaloside IV(AS-IV)for insulin resistance(IR)and type 2 diabet es mellitus(T2DM).METHODS:CCK8 kit was used to detect cell viability,glucose detec...
关键词：AstragalosideⅣ Insulin resistance Glucose consumption ROS JNK HepG2 cells 
AstragalosideⅣplays a role in reducing radiation-induced liver inflammation in mice by inhibiting thioredoxin-interacting protein/nod-like receptor protein 3 signaling pathway被引量：1
《Journal of Traditional Chinese Medicine》2023年第1期87-94,共8页DING Yanping DONG Xiaoqing MA Yifan CHEN Lili ZHOU Jie LI Xinyan SHAO Baoping 
Supported by Natural Science Foundation-Funded Project:Molecular Mechanism of the Brain AQP4 Adaptation to the Extreme Hhypoxia in the Qinghai-Tibet Plateau Animal(No.31760271)。
OBJECTIVE:To investigate the efficacy of Astragaloside IV(AS-IV)on radiation-induced liver inflammation in mice.METHODS:The mice were divided into normal group,dimethyl sulfoxide solvent group,irradiation group(IR),ir...
关键词：radiation ionizing astragalosideⅣ liver inflammation NLR family pyrin domain-containing 3 protein thioredoxin-interacting protein 
Review of the pharmacological effects of astragalosideⅣand its autophagic mechanism in association with inflammation被引量：9
《World Journal of Clinical Cases》2022年第28期10004-10016,共13页Ying Yang Meng Hong Wen-Wen Lian Zhi Chen 
Supported by Project of Zhejiang Traditional Chinese Medicine Technology,No.2018ZA063;Chinese National Natural and Science Foundation,No.81700552;Natural Science Fund Committee of Zhejiang Province,No.LQ20C200010。
Astragalus membranaceus Bunge,known as Huangqi,has been used to treat various diseases for a long time.AstragalosideⅣ(AS-Ⅳ)is one of the primary active ingredients of the aqueous Huangqi extract.Many experimental mo...
关键词：AstragalosideⅣ Pharmacological effect AUTOPHAGY INFLAMMATION 
Effect of astragaloside Ⅳ on the immunoregulatory function of adipose-derived mesenchymal stem cells from patients with psoriasis vulgaris
《Journal of Traditional Chinese Medicine》2022年第4期513-519,共7页YIN Xiuping ZHANG Xiaotong ZHU Rongjia SONG Ping 
Supported by the National Natural Science Foundation of China Project:Exploring the Immune Mechanism of Kaixuan Jiedu Method in the Treatment of Psoriasis based on the Hypoxia Sensing Pathway Mediating Th17/Treg Imbalance(No.82074448)
OBJECTⅣE:To compare the phenotype and adipogenic and osteogenic differentiation capacities of adiposederived mesenchymal stem cells(AMSCs)isolated from patients with psoriasis vulgaris and healthy donors,and to explo...
关键词：PSORIASIS mesenchymal stem cells cell proliferation astragalosideⅣ ADIPOGENESIS OSTEOGENESIS immune regulation 
AstragalosideⅣimproves melanocyte differentiation from mouse bone marrow mesenchymal stem cells
《BIOCELL》2021年第6期1551-1559,共9页XINGYU MEI ZHOUWEI WU CHENGZHONG ZHANG YUE SUN WEIMIN SHI 
the National Natural Science Foundation of China(Grant No.81703140).
Vitiligo results in an autoimmune disorder destructing skin pigment cells,melanocytes(Mcs).This study aimed to investigate whether Astragaloside IV(AIV)could efficiently induce differentiation of bone marrow mesenchym...
关键词：Tyrosinase-related protein Melanoma antigen recognized by T cells 1 Microphthalmia-associated transcription factor Committed differentiation Traditional Chinese medicine 
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging被引量：15
《Acta Pharmaceutica Sinica B》2021年第11期3665-3677,共13页Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz 
supported by the National Natural Science Foundation of China(No.81803483,No.21927808);National Key Research and Development Program of China(No.2017YFC1704006)。
Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the...
关键词：Spatial-resolved metabolomics Mass spectrometry imaging Diabetic nephropathy Metabolic reprogramming AstragalosideⅣ 
Astragaloside Ⅳ suppresses post-ischemic natural killer cell infiltration and activation in the brain:involvement of histone deacetylase inhibition被引量：7
《Frontiers of Medicine》2021年第1期79-90,共12页Baokai Dou Shichun Li Luyao Wei Lixin Wang Shiguo Zhu Zhengtao Wang Zunji Ke Kaixian Chen Zhifei Wang 
supported by the National Natural Science Foundation of China(Nos.81503055 and 81873029);Shanghai Youth Eastern Scholar(No.QD2015037).
Natural killer(NK)cells,a type of cytotoxic lymphocytes,can infiltrate into ischemic brain and exacerbate neuronal cell death.Astragaloside Ⅳ(ASIV)is the major bioactive ingredient of Astragalus membranaceus,a Chines...
关键词：astragalosideⅣ brain ischemia natural killer cells histone deacetylase nuclear factor-κB 
Astragaloside 对实验性自身免疫性脑脊髓炎小鼠的防治作用研究被引量：4
《中国免疫学杂志》2019年第23期2848-2852,共5页刘建春 张红珍 郭文娟 柴智 尉杰忠 于婧文 肖保国 马存根 
国家自然科学基金2014年面上项目(81473577);黄芪资源产业化及产业国际化协同创新中心项目(HQXTCXZX2016-020);山西中医药大学科技创新能力培育计划项目(2019PY-027)
目的:探讨Astragaloside对实验性自身免疫性脑脊髓炎(EAE)小鼠的保护作用及机制。方法:采用髓鞘MOG 35-55诱导C57BL/6雌性小鼠建立EAE模型,随机分为EAE对照组、Astragaloside高、低剂量组。造模的第3天起,采用腹腔注射给药,持续25 d。EA...
关键词：实验性自身免疫性脑脊髓炎 ASTRAGALOSIDE 炎性因子 ROCK通路 
Effect of astragaloside Ⅳ on lipid and glucose metabolism in acute myocardial infarction through PPARγ pathway被引量：2
《中国药理学与毒理学杂志》2019年第9期680-681,共2页ZHANG Qian WANG Xiao-ping WANG Yong LI Chun WANG Wei 
National Natural Science Foundation of China(81530100,81673802,81673712,81822049)。
OBJECTIVE To investigate the effects of astragaloside IV(which can be extracted from the traditional Chinese medicine Astragalus membranaceus)on lipid and glucose metabolism in acute myocardial infarction(AMI).METHODS...
关键词：acute MYOCARDIAL INFARCTION astragalosideⅣ lipid and glucose metabolism PPARγpathway 
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