Review of the pharmacological effects of astragalosideⅣand its autophagic mechanism in association with inflammation  

作　　者：Ying Yang Meng Hong Wen-Wen Lian Zhi Chen 

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,National Medical Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第28期10004-10016,共13页世界临床病例杂志

基　　金：Supported by Project of Zhejiang Traditional Chinese Medicine Technology,No.2018ZA063;Chinese National Natural and Science Foundation,No.81700552;Natural Science Fund Committee of Zhejiang Province,No.LQ20C200010。

摘　　要：Astragalus membranaceus Bunge,known as Huangqi,has been used to treat various diseases for a long time.AstragalosideⅣ(AS-Ⅳ)is one of the primary active ingredients of the aqueous Huangqi extract.Many experimental models have shown that AS-Ⅳexerts broad beneficial effects on cardiovascular disease,nervous system diseases,lung disease,diabetes,organ injury,kidney disease,and gynaecological diseases.This review demonstrates and summarizes the structure,solubility,pharmacokinetics,toxicity,pharmacological effects,and autophagic mechanism of AS-Ⅳ.The autophagic effects are associated with multiple signalling pathways in experimental models,including the PI3KI/Akt/m TOR,PI3KⅢ/Beclin-1/Bcl-2,PI3K/Akt,AMPK/m TOR,PI3K/Akt/m TOR,SIRT1–NF-κB,PI3K/AKT/AS160,and TGF-β/Smad signalling pathways.Based on this evidence,AS-Ⅳcould be used as a replacement therapy for treating the multiple diseases referenced above.

关 键 词：AstragalosideⅣ Pharmacological effect AUTOPHAGY INFLAMMATION 

分 类 号：R285[医药卫生—中药学]