乳腺癌和乳腺良性肿物体表傅里叶变换红外光谱研究  

Superficial detection of breast mass by fourier transform infrared spectroscopy： caner versus the benign

作　　者：高梅娟[1,3] 徐怡庄[2] 赵瑾[1] 徐智[1] 雷玉涛[1] 赵红梅[1] 周孝思[1] 吴瑾光[1] 凌晓锋[1] 

机构地区：[1]北京大学第三医院普通外科,100083 [2]北京大学化学学院 [3]北京工业大学医院

出　　处：《中华实验外科杂志》2011年第5期668-669,共2页Chinese Journal of Experimental Surgery

基　　金：北京市自然科学基金资助项目（2072020）

摘　　要：目的探讨利用傅里叶变换红外（F13R）光谱技术鉴别乳腺癌和乳腺良性肿物的可行性。方法联合运用衰减全反射（ATR）探头与中红外光纤、FTIR光谱分析仪，测定26例乳腺癌患者和34例乳腺良性肿物患者体表的VYIR光谱，比较两组光谱各个谱带的峰位（P）、相对峰强（I）及半高宽指标（F），总结乳腺癌体表光谱的特征。结果与乳腺良性肿物体表光谱比较，乳腺癌体表光谱中（1）蛋白质酰胺II带P1546发生明显地红移（向低波数移动，P〈0．05）；（2）与核酸相关的相对峰强I1256／I1460（P〈0．05）明显升高；（3）与C—H或C-O-H的变角振动的谱带峰位P1303发生明显地红移（向低波数移动）（P〈0．05）。结论乳腺癌体表FTIR光谱与乳腺良性肿物体表的光谱比较，在蛋白质、核酸和脂类相关谱带均有明显差异。Objective To explore the feasibility of superficially diffferentiating breast cancer from the benign fourier transform infrared （FTIR） spectroscopy. Methods Twenty-six cases of breast cancer and 34 cases of the benign were examined superficially by FI＇IR spectroscopy. For each FTIR spectrum, the peak positions （P）, relative intensity （I） and full width at half maximum （F） of the band were recorded and the relative intensity ratios were calculated. Results In the group of breast cancer, both the peaks of 1546 cm-1 and 1303 cm- 1 shifted toward lower wave number （P 〈 0. 05 ）, as compared to those of the benign group. The relative intensity ratio of I1256/I1460 was increased significantly （ P 〈 0. 05 ）. Conclusion There existed many significant differences in FTIR spectra between malignant and benign breast

关 键 词：乳腺癌 光谱 

分 类 号：R737.9[医药卫生—肿瘤]