乳腺浸润性导管癌钼靶X线表现与腋窝淋巴结转移及p53蛋白表达的关系  

Relationship of mammography, lymph node metastasis, and p53 protein expression in infiltrating ductal breast carcinoma

作　　者：林黎娟[1] 曹中良[2] 林贞花[3] 张晓燕[4] 张锦辉[1] 王研[1] 

机构地区：[1]辽东学院医学院,辽宁丹东118002 [2]辽宁丹东市中心医院外科 [3]延边大学医学院 [4]沈阳市第五医院

出　　处：《中华实验外科杂志》2011年第5期679-680,F0003,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（30960120）;吉林省科技厅社会发展重点项目（20090442）

摘　　要：目的探讨乳腺浸润性导管癌X线征象与腋窝淋巴结转移、p53蛋白表达的关系。方法观察72例浸润性导管癌的X线征象及腋窝淋巴结转移状况，应用免疫组织化学检测p53表达，分析乳腺癌X线征象与腋窝淋巴结转移、p53表达的关系。结果淋巴结转移组p53阳性表达率56．7％，较未转移组31．4％高（P〈0．05）；≥2cm组和血管增粗组p53阳性表达率、淋巴结转移率分别为66．7％、70．0％和56．4％、66．7％，均较〈2cm组28．6％、38．1％和血管正常组30．3％、33．3％高（P均〈0．01）；毛刺组淋巴结转移率70．8％高于无毛刺组41．7％（P〈0．05）。结论乳腺癌X线征象可评价腋窝淋巴结转移及p53表达，为临床诊治及预后判断提供参考。Objective To investigate the relationship among the mammography signs, the axillary lymph node （LN） metastasis, and the p53 expression of infiltrating ductal breast carcinoma. Methods Mammography signs and axillary LN metastasis were analyzed in 72 cases of infiltrating ductal carcinoma. Immunohistochemistry was used to detect p53 expression in tumor specimens. The relationship among the mammography signs, the axillary LN metastasis and the p53 expression was assessed. Results The positive rate of p53 expression was 56. 7% in the patients with axillary LN metastasis, which was higher than 31.4% in the patients without axiUary LN metastasis （ P 〈 0. 05 ）. The rate of axillary LN metastasis and p53 expression were 66. 7% and 70. 0% in the tumors larger than 2 cm, 56. 4% and 66. 7% in the tumors with more vascular signs, 28. 6% and 38. 1% in the tumors less than 2 cm, 30. 3% and 33.3% in the tumors with normal vascular signs （ P 〈 0. 01 ）, respectively. The rate of axillary LN metastasis in the patients with spinulation was 70. 8%, which was higher than 41.7% of patients without spinulation （ P 〈 0. 05 ）. Conclusion Mammography signs of breast cancer can evaluate the axillary LN metastasis and p53 expression, and also can provide objective reference for clinical diagnosis, treatment and prognosis of breast carcinoma.

关 键 词：乳腺癌 腋窝淋巴结 转移 P53 

分 类 号：R737.9[医药卫生—肿瘤]