白念珠菌DNA损伤与修复  

Research progress of DNA damage and repair in Candida albicans

作　　者：李星星[1] 阎澜[1] 姜远英[1] 

机构地区：[1]第二军医大学药学院新药研究中心,上海200433

出　　处：《生命的化学》2011年第2期216-221,共6页Chemistry of Life

摘　　要：内外环境中各种因素如电离辐射、紫外辐射、氧化剂、烷化剂等都可以造成白念珠菌DNA的损伤。如果DNA的损伤得不到有效的修复,便会造成突变。白念珠菌的突变率很高,但并不是所有DNA受损伤的细胞都会表现出突变型性状,这跟其自身的修复系统有很大关系,主要包括切除修复、错配修复及双链断裂修复等途径,使得绝大多数损伤能够及时修复,从而维持DNA的完整性与稳定性。白念珠菌DNA的损伤修复可能影响其适应性、药物敏感性等表型,从而给临床感染患者的治疗增加难度。本文主要从白念珠菌DNA损伤的产生,损伤信号的传导识别及损伤修复三方面综述目前的研究进展。There are so many internal and external environmental factors that could cause DNA damage in Candida albicans,such as ionizing radiation,ultraviolet radiation,oxidants,alkylating agent,and so on.It would result in mutations if DNA damages are not repaired effectively.Although the mutation rate is high in C.albicans,not all DNA-damaged cells show the mutant trait,which depends on their own repair system.The repair system,including excision repair,mismatch repair,double strand break repair and other pathways,enables most damages to be repaired in time in order to maintain the integrity and stability of DNA.DNA damage and repair system in C.albicans would affect its adaptability,drug sensitivity and other phenotypes,which increase the difficulty of clinical treatment of infections.This review summarizes the research progress about the cause of DNA damage,identification of the damage signal transduction and damage repairs in C.albicans.

关 键 词：白念珠菌 DNA损伤 DNA修复 逆转座子 

分 类 号：R379[医药卫生—病原生物学]