SHIP蛋白质的生物学特性及其与白血病的关系  

Biological characteristics of SHIP and its relationship with leukemia

作　　者：谭博[1] 张殿政[1,2] 陈汉春[1] 

机构地区：[1]中南大学生物科学与技术学院生物化学系 [2]Department of Biochemistry/Molecular Biology,Philadelphia College of Osteopathic Medicine,Philadelphia,PA 19131,USA

出　　处：《生命的化学》2011年第2期244-247,共4页Chemistry of Life

基　　金：国家自然科学基金项目(30371660);中南大学贵重仪器设备开放共享基金和中南大学研究生教育创新工程项目资助

摘　　要：含SH2结构域的肌醇磷酸酶(SHIP)属于5’磷酸酯酶家族成员。SHIP能将磷脂酰肌醇-3,4,5-三磷酸(PI-3,4,5-P3,PIP3)水解为磷脂酰肌醇-3,4-二磷酸(PI-3,4-P2),是主要表达于造血细胞的磷脂酰肌醇3-激酶(PI3K)信号抑制分子,通过参与调节PI3K途径而影响细胞增殖、存活及信号转导等诸多细胞活动,与白血病的发生发展密切相关。The SH2 domain-containing inositol 5’-phosphatase（SHIP） is a member of the 5’-phosphatase family.SHIP confers 5’-phosphatase enzymatic activity and specifically hydrolyzes the 5’ phosphate from PI-3,4,5-P3 to produce PI-3,4-P2.Therefore,SHIP plays an important regulatory role in the PI3K pathway by controlling the concentrations of PI-3,4,5-P3.Since the expression of SHIP is highly restricted to hematopoietic cells and affects cellular proliferation,survival and signal transduction,the activity of SHIP is closely related to the development of leukemia.

关 键 词：SHIP 磷脂酰肌醇3-激酶 白血病 

分 类 号：R733.7[医药卫生—肿瘤]