猫运动区青霉素诱发致痫灶手术治疗方法实验研究 第Ⅱ部分:致痫灶皮层手术处理的病理学观察  

The experimental surgical technique research of cats sensorimotor area cortex epileptogenic focus-induced by peniciling.Ⅱ.Histology observation

作　　者：蒙和[1] 栾国明[1] 张颖[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科,100050

出　　处：《立体定向和功能性神经外科杂志》1999年第3期49-52,共4页Chinese Journal of Stereotactic and Functional Neurosurgery

基　　金：北京市科委资助课题

摘　　要：目的 :比较多软膜下横纤维切断术和射频、激光技术在皮层形态学上的改变 ,为激光和射频技术选择适宜的参数提供科学的依据。方法 :第一部分实验动物在手术一周后 ,心脏灌注、取脑、固定、制备常规组织学切片 (H E染色 ) ,肉眼和显微镜观察各实验组形态学变化。结果 :横切刀技术组的损伤为贯穿皮层的裂隙 ,周围为损伤后的修复。射频和激光技术具有相同的病理变化 ,只是损伤的程度不同 ,均表现为火山口样变化 ,周围组织为损伤修复。或表现为底边位于皮层表面的楔性凝固坏死灶。结论 :本研究射频和激光的病理损伤程度要大于横切刀所造成的损伤 ,因此这两种技术的参数还有待于进一步选择和调整。Objective:Radiofrequency,laser and transection techniques are compared in morphiology in order to select the optimal parameter.Method:A week after operation,the experiment animal are perfused transcardia,ablation brain,fixation,and produced the conventional pathology section(H-E).The morphiology changes are observed by naked eye and microscope.Result:The results of RF and laser illustrated that the lesions appeared as volcano shaped coagulation necrosis was surrounded by an area of macrophagic reaction,angiogenesis and gliosis.The subpial transection subgroups shows the crevice-shaped,which was surounded by gliosis,and filled with hemorrhage in the cavity.Conclusion:The damage of radiofrequency and laser techniques are severer than that transector technique,so the parameter of this technique shoule be adjusted deeply.

关 键 词：青霉素 癫痫 动物模型 发病机制 

分 类 号：R742.102[医药卫生—神经病学与精神病学]