CXCR4／CXCL12轴与白血病复发  

CXCR4/CXCL12 axis and relapsed leukemia

作　　者：姚红章[1] 高瑞兰[1] 

机构地区：[1]浙江中医药大学附属第一医院血液病研究所,杭州310006

出　　处：《国际肿瘤学杂志》2011年第4期303-306,共4页Journal of International Oncology

摘　　要：趋化因子受体CXCR4与其特异性配体CXCL12结合,启动下游信号通路形成CXCR4/CXCL12生物轴,在造血干细胞的归巢、再植以及维持正常造血和造血微环境的稳定过程中发挥重要作用.CXCR4/CXCL12轴同时也可促进白血病细胞存活、增殖、转移及耐药,与白血病髓内外复发关系密切.CXCR4的表达水平可作为判断白血病患者预后的重要指标之一,同时CXCR4抑制剂与常规化疗药物联合使用是白血病治疗的新方向.The binding complex of chemokine receptor CXCR4 and its specific ligand CXCL12 triggers the downstream signaling pathway to form biological axis of CXCR4/CXCL12. The axis plays an important role in homing,repopulation of hematopoietic stem cells, as well as maintenance of normal hematopoiesis and homeostasis of hematopoietie microenvironment. Meanwhile, CXCR4/CXCL12 axis is also closely related with relapsed leukemia, since it may promote survival, proliferation, metastasis and drug resistance in leukemic cells. The expression level of CXCR4 could be treated as an important marker for predicting prognosis in patients with leukemia, therefore, the combination of CXCR4 inhibitors with routine chemotherapy may represent a powerful approach for the treatment of leukemia.

关 键 词：受体 CXCR4 趋化因子CXCL12 信号传导 白血病 肿瘤 残余 

分 类 号：R733.7[医药卫生—肿瘤]