针刺上巨虚穴对慢性内脏痛敏肠易激综合征模型大鼠血清胃肠激素的影响  

Effects of acupuncture on Shangjuxu Point on gastrointestinal hormone in serum of rats models with irritable bowel syndrome of chronic visceral hypersensitivity

作　　者：王威[1] 张燕[1] 吕恩基[1] 高志雄[1] 赵金茹[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032

出　　处：《甘肃中医学院学报》2011年第2期5-7,共3页Journal of Gansu College of Traditional Chinese Medicine

基　　金：2008年度辽宁省科技厅科学自然基金资助项目(20082068);2010年度辽宁省教育厅科学研究项目(12010367)

摘　　要：目的观察针刺上巨虚穴对慢性内脏痛敏肠易激综合征(IBS)模型大鼠胃动素(MTL)、生长抑素(SS)的影响。方法将30只雄性SD大鼠随机分为空白组、模型组、电针组,其中模型组和电针组大鼠采用直肠球囊扩张刺激法持续刺激15 d制备慢性内脏痛敏IBS模型。电针组隔日1次针刺双侧上巨虚穴10 d,采用放射免疫分析法检测各组大鼠血清MTL和SS含量。结果与空白组比较,模型组大鼠血清MTL、SS含量显著升高(P<0.01);与模型组比较,电针组大鼠血清MTL、SS含量显著降低(P<0.01或P<0.05)。结论降低慢性内脏痛敏IBS模型大鼠血清MTL和SS含量,可能是针刺调节IBS胃肠运动、进而改善慢性内脏痛敏症状的关键机制之一。Objective To observe the effects of acupuncture on Shangjuxu Point（ST37） on motilin（MTL） and somatostatin（SS） in rats models with irritable bowel syndrome（IBS） of chronic visceral hypersensitivity.Methods 30 male SD rats were randomly devided into 3 groups： blank group,model group and electro-acupuncture group.The rats of model group and electro-acupuncture group were made into IBS models with chronic visceral hypersensitivity by the stimulus method of balloon expansion in rectum for fifteen days.The rats of electro-acupuncture group were acupunctured ST37 on both side of the body one time in two days,which would be lasting for ten days,and the contents of MTL and SS in serum of all rats were detected by RIA.Results Compared with blank group,the contents of MT and SS of model group were significantly increased（P〈0.01）,and were markedly lower than model group in electro-acupuncture group（P〈0.01 or P〈0.05）.Conclusion To reduce the content of MTL and SS maybe a key mechanism in regulating gastrointestinal motility by acupuncture and improving chronic visceral hypersensitivity.

关 键 词：针刺机制 肠易激综合征 胃动素 生长抑素 

分 类 号：R574.4[医药卫生—消化系统]