新基因HA117在肠腺癌中的表达及意义  

Study on expression and significance of novel gene HA117 in colorectal adenocarcinoma

作　　者：李昆昆[1] 金先庆[1] 赵利华[1] 丁雄辉[1] 陈建飞[1] 孙艳辉[1] 牟廷刚[1] 王士奇[1] 

机构地区：[1]重庆医科大学附属儿童医院普外科,400014

出　　处：《重庆医学》2011年第14期1358-1360,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(39970768)

摘　　要：目的研究新基因HA117在肠腺癌细胞中的表达位置和分布情况,了解其与肠腺癌各临床病例特征的关系。方法应用免疫组化SP法,检测20例肠腺癌和10例结肠正常组织中HA117的表达。结果 HA117在肠腺癌中的表达阳性率为75%,在正常结肠组织中的表达阳性率为10%,其结果差异有统计学意义（P=0.001）;结肠癌组织中的阳性表达率显著高于直肠癌组织和正常结肠组织（P=0.002）。在Ⅲ~Ⅳ期组织中的表达阳性率比Ⅰ~Ⅱ期高,有淋巴结转移组的表达阳性率比无淋巴结转移组高,低分化组的表达阳性率比中高分化组高,但其结果差异均无统计学意义（P〉0.05）。结论 HA117在肠腺癌中有着广泛的分布,从而提示实体肿瘤对化疗药物的耐受性同样受HA117基因的影响。Objective To study the specific position and the distribution of the novel gene HA117 and to realize the relationship between HA117 and colorectal adenocarcinoma clinicopathologic features.Methods HA117 was detected in 20 cases of colorectal adenocarcinoma and 10 cases of normal colon with immunohistochemistry method.Results The positive expression rate of HA117 in colorectal adenocarcinoma and normal colon was 75% and 10%,with statistical significance（P=0.001）;HA117 positive expression rate in colon carcinoma was significantly higher compared with rectum carcinoma and the normal colonic structure（P=0.002）.HA117 positive expression rate in Ⅲ-Ⅳ stages was higher than that inⅠ-Ⅱ stages;the rate was higher in the lymph node metastasis group compared with no lymph node metastasis group;the rate was higher in the poor differentiated group compared with well-differentiated group;but these results had no statistical significance（P0.05）.Conclusion The distribution of HA117 in colorectal adenocarcinoma is extensive,which suggests that the tolerance toward chemotherapeutics would also be affected by gene HA117.

关 键 词：基因 免疫组织化学 HA117 肠腺癌 

分 类 号：R735.3[医药卫生—肿瘤]