埃索美拉唑与奥美拉唑治疗内镜黏膜下剥离术术后并发症的对比观察  

Comparison of endoscopic submucosal dissection postoperative complications treated with esomeprazole and omeprazole

作　　者：杨均[1] 余建华 肖潇[1] 孙文静[1] 沈小春[1] 傅鑫[1] 邢寒阳[1] 胡辂[1] 

机构地区：[1]第三军医大学大坪医院消化内科,重庆400042 [2]重庆市綦江县人民医院内科,401420

出　　处：《重庆医学》2011年第14期1397-1398,共2页Chongqing medicine

摘　　要：目的观察埃索美拉唑与奥美拉唑治疗内镜黏膜下剥离术(ESD)术后并发症的疗效。方法随机双盲将41例行ESD治疗患者分为两组:A组20例,给予埃索美拉唑40 mg静脉注射,2次/日,疗程7 d,后序贯口服埃索美拉唑40 mg;B组21例,给予奥美拉唑静脉注射,2次/日,疗程7 d,序贯口服奥美拉唑40 mg。比较两组腹痛、创面溃疡愈合、消化道出血及不良反应情况。结果两组腹痛缓解的时间比较差异无统计学意义(P>0.05),创面愈合在7 d时埃索美拉唑组与奥美拉唑组比较,差异有统计学意义(P<0.05),14 d后A、B两组比较差异均无统计学意义(P>0.05),不良反应比较差异无统计学意义(P>0.05)。结论埃索美拉唑能更早促进ESD术后创面溃疡的愈合。Objective To compare the therapeutic effect of the endoscopic submucosal dissection（ESD） postoperative complications treated with esomeprazole and omeprazole.Methods 20 patients with ESD were randomized to observation group with 21 cases and control group with 41 cases.The observation group was administered esomeprazole（40mg twice a day）,omeprazole（40mg twice a day）for 7 d.The therapeutic effct of each drug such as auound surface healing and their symptoms such as stomachache,perforation and adverse reaction were observed.Results There was no statstic difference between both of the groups in the degree of the stomachache release（P0.05）.There was statistic difference between both of the groups in wound surface healing after 7 d postoperation（P0.05）,but there was no difference after postoperative 14 d（P0.05）.Less adverse reaction was observed in both groups.Conclusion Effects of esomeprazole can promote the earlier healing of wound surface after ESD.

关 键 词：奥美拉唑 手术后并发症 内镜黏膜下剥离术 上皮内瘤变 胃早癌 埃索美拉唑 

分 类 号：R735.2[医药卫生—肿瘤]