G-蛋白对吗啡舒张血管机制的探讨  

To study the effects of G-protion on the relative factors of morphine relaxing aortic smooth muscle strip

作　　者：许琴[1] 魏振宇[1] 俞安清[1] 任伟[1] 

机构地区：[1]遵义医学院生理学教研室

出　　处：《遵义医学院学报》1999年第3期18-19,共2页Journal of Zunyi Medical University

摘　　要：目的探讨G-蛋白是否参与了吗啡的舒血管效应。方法用G-蛋白抑制剂百日咳毒素（PTX）孵育血管条8～10h，观察吗啡对血管条的作用。结果吗啡使脱羟肾上腺素（PE）预收缩的血管条舒张，舒张百分数为26.8％±0.4％，较对照明显增强，P＜0.001，使PE预收缩的血管条（经PTX预孵育）舒张;与对照组相比，舒张10min、20min两组之间有显著差异P＜0.05。结论吗啡可抑制PE引起的主动脉血管平滑肌细胞膜受体依赖钙通道（ROC）的开放，阻止外钙内流。吗啡的舒血管效应可能有G-蛋白参与。Objctive To study the effects of guanine nucleotide-binding protein (G-protein) on the relative factors of morphine relaxing aortic smooth muscle strip. Methods Using G-protein inhibitor PTX marinate aortic smooth musle strip (8-10h). We investigated effects of morphine on aortic smooth muscle strip. Results it showed that Morphine made aortic smooth muscle strip which with PE contracted relaxing, Percent of relaxing is 26. 8% ±0. 4%. It is higher than contrast P < 0. 001. Morphine made aortic smooth muscle strip which with PE contracted and PTX marinated (8-10h) relaxing, 10min 20min percent of relaxing is higher than contrast P < 0. 05. conclusions These findings indicate that morphine inhibite opening of calcium-channel which receptor couphing in aortic smooth muscle strip, the relaxing effect of morphine on aortic smooth muscle strip is mediated by Gprotion.

关 键 词：吗啡 血管条 G蛋白 百日咳毒素 

分 类 号：R971.1[医药卫生—药品] R391.32[医药卫生—药学]