盐酸二氢埃托啡酯衍生物的制备与药理性质  

Preparations and Pharm acological Propertiesof Dihydroetorphine Ester Derivatives

作　　者：何军林[1] 龚雄麒[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《药学进展》1999年第4期237-240,共4页Progress in Pharmaceutical Sciences

摘　　要：为改进盐酸二氢埃托啡的药理性质，制备了它的 ７ 个酯衍生物，测定了这些化合物的油水分配系数。药理实验表明，其半数有效剂量增加，药效时间均比盐酸二氢埃托啡长，成瘾性也强于盐酸二氢埃托啡。In order to im prove the pharm acological properties of dihydroetorphine hy drochloride including duration of action and efficiency, w e prepared its six esters and testedtheir pharm acological properties ( E D50 and T1/2 ). The results show ed that all the derivativeshad longer duration of action than that of the parent com pound ,but w ith decreased efficien cies.

关 键 词：盐酸二氢埃托啡 酯衍生物 药理性质 制备 

分 类 号：R971.1[医药卫生—药品]