微波辐射在合成沙利度胺中的应用  

Application of the microwave-assisted method in synthesis of thalidomide

作　　者：尤思路[1,2] 李鹰[3] 陈丹[1] 郑勇胜[1] 王淑燕[1] 徐克磊[1] 成丽[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]成都医学院药学院实验技术中心,四川成都610083 [3]四川大学生命科学院,四川成都610064

出　　处：《化学研究与应用》2011年第5期652-656,共5页Chemical Research and Application

基　　金：四川省科技厅资助项目(2009JY0034);四川大学实验技术立项(精品实验)资助项目(2008-02;2008-01);四川省高等教育人才培养质量和教学改革项目(第一批)资助(P09050)

摘　　要：以邻苯二甲酸酐和尿素为原料,应用微波辐射加热技术,共经过四步合成目标产物沙利度胺的方法,且产物不需要经过多次纯化。考察了辐射功率、辐射时间、原料配比、溶剂用量等对收率的影响。与常规加热方法合成沙利度胺比较,微波辅助合成在提高产率的同时大大缩短了反应时间,且具有操作简单、环境污染小、产品质量好等优点。In this paper,phthalic anhydride and urea were used as raw materials for the synthesis of the target compounds,thalidomide via four steps reaction with microwave heating method,and the sequence requires no purifications.The affecting factors on the yield were observed.Compared with conventional heating method,microwave assisted synthesis had many advantages such as simplicity of operation,no pollution,good quality for the sample,and the reaction time was greatly shortened with improved yield.The structures were confirmed by 1H-NMR spectra and MS spectra.

关 键 词：微波辐射 沙利度胺 微波辅助合成 物理加热 

分 类 号：O621.3[理学—有机化学]