青海汉族、回族、藏族MICA-TM基因多态性与胃癌相关性  

ASSOCIATION OF MICA-TM GENE POLYMORPHISM AND GASTRIC CANCER RISK AMONG HAN HUI TIBETAN THREE ETHNICS IN QINGHAI PROVINCE

作　　者：邢永华[1] 杨生玺[1] 吕同德[2] 哈小琴[2] 耿排力[1] 

机构地区：[1]青海大学医学院基础医学部 [2]兰州军区总医院医学实验中心

出　　处：《青海医学院学报》2011年第1期1-4,共4页Journal of Qinghai Medical College

基　　金：国家自然科学基金项目(No:30660174);青海省重点科技攻关基金项目(No:2006-N-175)

摘　　要：目的分析青海汉族、回族、藏族MICA-TM基因多态性与胃癌相关性。方法以特异引物聚合酶链法扩增青海汉族、回族、藏族胃癌患者(病例组)MICA-TM基因特异序列,直接测序分型技术检测等位基因频率分布情况,并与健康人群(对照组)进行对比分析。结果病例组检测出*A4、*A5、*A5.1、*A6、*A7、*A8、*A9等7种MICA-TM等位基因;回族、藏族病例组*A5、*A5.1等位基因分布频率有差别(χ2=8.003,P<0.05;χ2=23.300,P<0.05);与对照组对比分析,回族病例组*A5.1等位基因分布频率高于回族对照组人群(χ2=9.181,P=0.002;OR=3.692,95%CI=1.559～8.746)。结论回族人群中MICAA5.1等位基因与胃癌发生可能相关。Objective To investigate association between MICA-TM polymorphism and gastric cancer risk by exploring the frequency and distribution of MICA-TM alleles in the gastric cancer patients among three nationalities in Qinghai province.Methods MICA-TM polymorphisms were studied in Han,Hui and Tibetan nationalities in Qinghai by using polymerase chain reaction sequencing based typing（PCR-SBT）,and compared them with controls.Results ＊A4,＊A5,＊A5.1,＊A6,＊A7,＊A8 and ＊A9 seven alleles shown in gastric cancer patients.The ＊A5,＊A5.1 alleles showed significant deference between Hui and Tibetan patients（χ2=8.003,P〈0.05;χ2=23.300,P〈0.05）,and also,＊A5.1 alleles of Hui were significantly higher than those of controls（χ2=9.181,P=0.002;OR=3.692,95%CI=1.5598.746）. Conclusion MICA ＊A5.1 of Hui nationality may be associated with gastric cancer susceptibility.

关 键 词：民族 胃癌 MICA—TM 等位基因 相关性 

分 类 号：Q751[生物学—分子生物学]