消化系统恶性肿瘤患者细胞免疫功能分析及其临床意义  

Clinical significance and analysis of cellular immunity functional on patients with digestive system malignant tumor

作　　者：姚伯程[1] 田文斌[2] 赵晓玲[1] 田淑琴 魏敏[2] 

机构地区：[1]甘肃省医学科学研究院,甘肃兰州730050 [2]甘肃省肿瘤医院,甘肃兰州730050 [3]甘肃省中医学校,甘肃兰州730050

出　　处：《甘肃医药》2011年第5期259-261,共3页Gansu Medical Journal

基　　金：甘肃省自然科学研究基金计划资助项目(1010RJZA144)

摘　　要：目的:检验消化系统恶性肿瘤患者外周血T淋巴细胞亚群,了解细胞免疫功能状态及其变化。方法:用实用McAb-A-E直接法检验消化系统恶性肿瘤患者72例及37例健康正常对照组的外周血抗凝血CD3+、CD4+、CD8+及CD4+/CD8+指标。并将恶性肿瘤组与健康正常对照组进行比较。结果:恶性肿瘤组CD3(+%)、CD4(+%)、CD8(+%)和CD4+/CD8+分别为:63.88±14.26、34.44±12.14、37.42±10.01和0.96±0.38;健康对照组分别为:69.24±9.46、44.41±5.96、33.30±4.38和1.35±0.20。恶性肿瘤组与健康对照组、正常值CD3+、CD4+、CD8+和CD4+/CD8+相比,恶性肿瘤组(食道癌、胃癌、肝癌、肠癌)CD3+和CD4+细胞阳性率和CD4+/CD8+比值均降低,CD8+细胞阳性率增高,方差分析结果均P<0.05和0.01,有统计学意义。结论:消化系统恶性肿瘤患者的CD3+、CD4+细胞阳性率和CD4+/CD8+比值均降低,CD8+细胞阳性率增高,说明消化系统恶性肿瘤患者的细胞免疫功能处于抑制状态。Objective：To detect T lymphocyte phenotype in peripheral blood of patients with digestive system malignant tumor in order to understand the change of cellular immunity function condition. Methods： T lymphocyte phenotype in peripheral blood from 72 cases of digestive system malignant tumor and 37 healthy controls were deteced by direct practically McAb-A-E in which results in two groups were compared. Results： CD3＋（%）,CD4＋（%）,CD8＋（%） and CD4＋/CD8＋ ratio in the digestive system malignant tumor group was respectively 63.88±14.26,34.44±12.14,37.42±10.01 and 0.96±0.38,and in the healthy control group was respectively 69.24±9.46,44.41±5.96,33.30±4.38 and 1.35±0.20.CD3＋,CD4＋ and CD4＋/CD8＋ ratio in the digestive system malignant tumor group was lower than that in the healthy control group（P0.05）.CD8＋ in the digestive system malignant tumor group was increase than that in the healthy control group（P0.01）. Conclusion： The immunity function of the digestive system malignant tumor is low and the inhibitory state.

关 键 词：消化系统恶性肿瘤 T淋巴细胞亚群 细胞免疫功能 检验 

分 类 号：R-05[医药卫生]