平阳霉素瘤腔注射治疗口腔颌面部静脉畸形的临床分析  

Clinical analysis of the effectiveness of intra-lesional injection of pingyangmycin in vascular malformations in oral and maxillofacial regions

作　　者：龚振宇[1] 李国华[1] 杨树忠[1] 林海[1] 李欣[1] 

机构地区：[1]南京军区福州总医院口腔科,福州350025

出　　处：《疑难病杂志》2011年第5期360-361,共2页Chinese Journal of Difficult and Complicated Cases

基　　金：福建省青年人才创新基金资助项目(No.2008F3089);福建省青年人才创新基金资助项目(No.2008F3088)

摘　　要：目的总结平阳霉素瘤腔注射治疗口腔颌面部静脉畸形的疗效,并分析不良反应的构成及对策。方法回顾分析2003年1月—2010年6月采用平阳霉素瘤腔注射治疗的颌面部静脉畸形患者227例241处瘤体,统计其疗效及不良反应。结果经过0.5～6年随访,治愈率为76.8%(185/241),好转14.5%(35/241),总有效率为91.3%。平均治疗次数为3次。发生不良反应19例(8.4%),其中发热11例,口腔黏膜溃疡3例,局部组织萎缩2例,注射部位组织坏死形成瘢痕愈合1例,过敏反应及晕厥各1例。结论平阳霉素瘤腔注射治疗口腔颌面部静脉畸形的疗效好,疗程短,是一种简便、安全、有效的方法。Objective To evaluate the effectiveness of intra-lesional injection of pingyangmycin in the treatment of vascular malformations in oral and maxillofacial regions.Methods From January 2003 to June 2010,a total of 227 patients with 241 lesions of vascular mallormalion in oral and maxillofacial region were treated with intra-lesional injection of pingyangmycin resolute with lidocaine and dexanethasone.Four weeks later these cases were reviewed and some of them received second time treatment if necessary.The efficacy of treatment and side effects occurred during the course were recorded.Results All of the 227 patients were followed up from 6 months to 6 years.The cure rates and elementary cure rates of vascular malformation were 76.8%（185/241 ） and 14.5%（35/241 ） respectively,the total effective rate was 91.3%.The average therapeutic times were 3.Side effects occurred in 19 patients（8.4%）.Among them,11 patients had fever,3 patients had mucosa ulceration, 2 patients had local tissue atrophy,1 patient had tissue necrosis at injection site,allergic response and syncope occurred in 1 patient respectively.Conclusion Intra-lesional injection of pingyangmycin is a simple,safe and effective therapeutic method to cure vascular malformations in oral and maxillofacial regions.

关 键 词：平阳霉素 静脉畸形 颌面部 瘤腔注射 

分 类 号：R739.8[医药卫生—肿瘤]