3项肿瘤标志物联合检测在肺癌诊断中的价值  

The evaluation of three tumor markers in diagnosis of lung cancer

作　　者：刘刚[1] 顾春瑜[1] 侯晓霞[1] 赵乔妹[1] 于勇[1] 

机构地区：[1]解放军总医院第一附属医院检验科,北京100048

出　　处：《感染．炎症．修复》2011年第1期43-45,共3页Infection Inflammation Repair

摘　　要：目的:探讨联合检测血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)水平对肺癌的诊断价值。方法:用电化学发光法检测113例肺癌确诊患者、60例肺良性病变患者血清中CEA、CYFRA21-1、NSE水平。结果:肺癌组CEA、CYFRA21-1、NSE检测阳性率均明显高于肺良性病变组(P<0.01);CEA、CYFRA21-1、NSE 3项联合检测肺癌的灵敏度为79.6%,明显高于单项检测肺癌的灵敏度(46.9%、46.9%和45.1%)和二项联合平行试验的诊断灵敏度(67.3%、70.8%和65.5%)。结论:CEA、CYFRA21-1、NSE联合检测可明显提高对肺癌的诊断灵敏度,有利于肺癌的早期诊断。Objective： To study the clinical significance of combination detection of carcino-embryonic antigen （CEA）, CYFRA21-1 and neuron-specific enolase （NSE） in patients with lung cancer. Methods： One hundred and thirteen cases of lung tumor patients and 60 patients with benign lung diseases were enrolled. Their serum levels of CEA, CYFRA21-1 and NSE were detected by electro-chemi-luminescence assay. Results： The levels of CEA, CYFRA21-1 and NSE in lung cancer group were significantly higher than those of control group （P〈0. 01）. The sensitivity and specificity of measurement of three tumor markers in combination （79. 60/40） were significantly higher than that of combination of two tumor markers（67.3%,70. 8% and 65.5% in different combinations）and single tumor marker（46.9%,46. 9% and 45.1%）. Conclusion： The combined measurement of serum CEA,CYFRA21-1 and NSE significantly increased the sensitivity for diagnosis of lung cancer, and therefore it provides useful information for early diagnosis of patients with lung cancer.

关 键 词：肺癌 癌胚抗原 细胞角蛋白19片段 神经元特异性烯醇化酶 

分 类 号：R734.2[医药卫生—肿瘤]