血浆hs-CRP、BNP、vWf在脑梗死TOAST分型中的意义  

Significance of plasma hs-CRP, BNP, vWf concentrations in TOAST classification of acute ischemic stroke

作　　者：谈鹰[1] 王庄[1] 诸金水[1] 王亚仙[1] 刘泉坤[1] 张冰[1] 钱福初[2] 许贻白[1] 

机构地区：[1]湖州市中心医院神经内科,313000 [2]湖州市中心医院中心实验室,313000

出　　处：《浙江医学》2011年第4期486-488,491,共4页Zhejiang Medical Journal

基　　金：基金项目：湖州市科技局基金项目（2008YS30）

摘　　要：目的 探讨血浆hs-CRP、BNP、vWf在脑梗死TOAST分型中的意义.方法 将脑梗死患者分为大动脉粥样硬化性脑梗死（LAA）组、小动脉闭塞性脑梗死（SAO）组、心源性脑梗死（CE）组,每组50例,并选取同期健康体检者50例作为对照组.通过检测LAA、SAO、CE各组血浆hs-CRP、BNP、vWf水平,与对照组比较,进行分析.结果 CE组血浆hs-CRP、BNP、vWf水平[（3.33±1.64）mg/L、（270.21±120.47）pg/ml、（31.12±6.59）ng/ml）]与对照组[（1.08±0.36） mg/L、（32.57±10.27） pg/ml、（8.65±3.09 ）ng/ml ）]比较差异均有统计学意义（均P＜0.01）,其中CE组血浆BNP、vWf水平与其他组比较均为最高 LAA组血浆hs-CRP、BNP水平[（8.86±3.58） mg/L、（110.47±42.30） pg/ml）]与对照组比较差异均有统计学意义（均P＜0.01）,血浆hs-CRP在各组中为最高,而vWf水平与对照组比较差异无统计学意义（P ＞0.05） SAO组血浆vWf水平[（12.47±4.54 ）ng/ml）]与对照组比较差异有统计学意义（P＜0.01）,血浆hs-CRP、BNP水平与对照组比较均无统计学意义（均P ＞0.05）.血浆hs-CRP、BNP、vWf水平不受平均动脉压、血糖、血胆固醇、LDL等的影响.结论 急性脑梗死患者血浆hs-CRP水平能辅助LAA的分型,BNP、vWf水平能辅助CE的分型.Objective To investigate the significance of plasma hs-CRP, BNP, vWf concentrations in TOAST classification of acute ischemic stroke.Methods Patients with acute ischemic stroke were divided into 3 subtypes according to TOAST classifi- cation： large-artery atherosclerosis （LAA）, cardioembolism（CE） and small-artery occlusion （SAO）. Plasma concentrations of high sensitivity C reaction protein （hs-CRP）, brain natriuretic peptide （BNP） and von Willebrand factor （vWf） were measured in patients and controls. Results There was statistical significance of plasma hs-CRP, BNP, vWf concentrations （3.33 ± 1.64rag/L, 270.21 ± 120.47pg/ml and 31.12 ± 6.59ng/ml in CE subtype of patients versus 1.08 ± 0.36mg/L, 32.57 ± 10.27 pg/ml and 8.65 ± 3.09ng/ml in controls）; plasma BNP, vWf concentrations were the highest among all subgroups. Plasma hs-CRP and BNP con- centrations （8.86 ± 3.58 mg/L and 110.47 ± 42.30 pg/ml） in LAA subtype were higher than those of control group with the highest plasma hs-CRP among all subtypes; but there was no significant difference in plasma vWf concentration （10.90 ± 4.58ng/ml） between LAA group and control group. Plasma vWf concentration （12.47 ± 4.54ng/ml） in SAO subtype was higher than that of con- trols, but there were no statistical differences in plasma hs-CRP and BNP concentrations （ 1.08 ± 0.66 mg/L, 28.43 ± 15.46 pg/ml } between SAO subgroup and control group. Plasma hs-CRP, BNP and vWf levels were not correlated with mean blood pressure, blood glucose, blood cholesterol and blood low density lipoprotein. Conclusion Plasma hs-CRP, BNP and vWf concentrations are of value in TOAST classification of acute ischemic stroke.

关 键 词：HS-CRP BNP VWF TOAST 分型 

分 类 号：R743.33[医药卫生—神经病学与精神病学]