口腔鳞癌患者血清、唾液Cyfra21-1含量检测的对比研究  

Oral Cavity Scale Cancer Patient Blood Serum, Saliva Cyfra21-1 Content Examination Contrast Research

作　　者：傅尧[1] 符义富[1] 游丽萍[1] 李兵[1] 

机构地区：[1]南京大学医学院附属口腔医院检验科,南京210008

出　　处：《现代检验医学杂志》2011年第2期74-75,77,共3页Journal of Modern Laboratory Medicine

基　　金：南京市医学科技发展重大项目（2007-24-）.

摘　　要：目的 检测口腔鳞癌（OSCC）患者血清、唾液中Cyfra21-1含量,探讨其在OSCC中的临床应用价值.方法 应用ELISA法同时检测43例OSCC患者（术前和术后）和35例正常对照者血清和唾液的Cyfra21-1水平,计算敏感度和特异度,并进行统计学处理.结果 OSCC组患者术前血清和唾液Cyfra21-1的含量分别为1.11±0.59 ng /ml和84.76±77 ng /ml,均显著高于正常对照组的0.33±0.20 ng /ml（t＝2.851,P＜0.01）和43.11±40.96 ng /ml（t＝3.112,P＜0.01）;并且在临床分期、肿瘤大小、淋巴结转移、是否原复发等方面差异均无统计学意义（P＞0.05）,但术后含量显著低于术前,分别下降到0.67±0.12 ng/ml和42.48±38 ng/ml,差异有统计学意义（t血清＝2.007,t唾液＝3.094,P＜0.05）.人体血清、唾液Cyfra21-1含量呈正相关（r=0.628）.OSCC组血清、唾液Cyfra21-1检测的敏感度、特异度分别为64.1%,88.6%和69.9%,94.7%.结论 血清、唾液中Cyfra21-1含量可作为OSCC的辅助诊断、疗效观察和预后监测的重要指标之一.Objective In the goal examination oral cavity scale cancer （OSCC） patient blood serum,the saliva the Cyfra21- 1 content,discusses it in the OSCC clinical practice value. Methods Simultaneously examinee 43 example OSCC patient after the ELISA law （technique and technique） and 35 example normal collator blood serum and the saliva Cyfra21-1 level, the computation sensitivity and the peculiarity and carries on statistics processing. Results The OSCC group patient blood serum and the saliva Cyfra21-1 content were 1. 11±0. 59 ng/ml and 84.76±77 ng/ml,respectively. It was higher than the normal control group （0. 33±0. 20 ng/ml,t=2. 851,P〈0. 01） and （43.11±40. 96 ng/ml,t=3. 112,P〈0.01）;And in clinical by stages,tumor size,lymph node shift,whether aspects and so on original recrudescence hadn＇t statistics significance （P〈0. 05）,but after the technique,before the content obviously was lower than the technique,drops separately to 0. 67 ±0. 12 ng/ml and 42.48±38 ng/ml ,It had statistics significance （tblood serum = 2. 007 ,tsaliva = 3. 094,P〈0. 05）. The human body blood serum,the saliva Cyfra21-1 content was being obviously related （r= 0. 628）. OSCC group blood serum, saliva Cyfra21-1 examination sensitivity,peculiarity were 64.1%,88.6% and 69.9% ,94.7%,respectively. Conclusion In of the conclusion blood serum,the saliva the Cyfra21-1 content may take OSCC one of the auxiliary diagnosis,the curative effect observation and prognosis monitor important targets.

关 键 词：口腔鳞癌 CYFRA21-1 肿瘤标志物 

分 类 号：R739.8[医药卫生—肿瘤] R730.43[医药卫生—临床医学]